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In Würzburg, experienced scientists and young researchers from all over the world come together to discuss the state of the art regarding the use of genetic modifications (e.g. genetic code expansion) for future biomedical treatments. The Translational Bioimaging Symposium 2022 Here, bioorthogonal click chemistry plays a key role – SiChem offers a wide range of […]
Milan Vrabel et al. believe that performing abiotic chemical reactions within particular organelles at the subcellular level opens up new avenues: by manipulating biological processes in a targeted manner, they can be studied in more detail and this strategy can also be used to develop organelle-targeted drug-delivery systems. (TCO-NHS / SC-8070 / SC-8072 / SC-8073) […]
Gerti Beliu et al. from the University of Würzburg use SiChem’s unnatural amino acid Trans-Cyclooct-2-en-L-Lysine (TCO*A; SC-8008 labelled with tetrazine dyes) for dSTORM experiments. A complete labelling and imaging pipeline has been developed to visualize transmembrane proteins in living neurons. Diogo Bessa-Neto et al. : NATURE COMMUNICATIONS (2021) 12: 6715: Bioorthogonal labeling of transmembrane proteins with […]
Neutrophils are often made responsible for killing bacteria in chronic diseases such as cystic fibrosis (CF). Here, however, there is an unexplained phenomenon: although neutrophils are massively present, long-lasting bacterial infections occur at the same time. Magaroli et al. from Emory University are trying to get to the bottom of this phenomenon and are also […]
Fluorescent probes that react with complementary bioorthogonal reagents and subsequently light up are excellent tools for bioimaging applications. Vrabel et al. have synthesized a series of diverse coumarin-tetrazine probes that can react with SiChem’s TCOs and BCNs in seconds to act as labels in living cells. (SC-8106 / SC-8406) Juraj Galeta, et al.: A […]
Bremen is rather known as a trading city – less as a high-tech location for internationally operating biotech companies. But there are quite a few innovative, research-based companies that offer their products and services worldwide. Some of them are now presented by the Wirtschaftsförderung Bremen – SiChem is one of them ! Stories about Bremen […]
Alkyl diazirines are photo-reactive functional groups frequently used in photo-affinity labeling (PAL). They are compact in size, being nearly isosteric to a methyl group, and they are activated at a wavelength of light (~355 nm) that is not damaging to protein(s). Photo-crosslinked protein targets are then visualized by the reporter group (e.g. fluorophore, biotin, or […]
SiChem receives BMWi grant (ZIM) together with TU Clausthal for developing Smart Simulated Moving Bed Chromatography (sSMB) Personalised medicine is about treating patients as individually as possible. The drugs administered should have an optimal effect. Often, the patient is given precisely tailored treatment strategies with several drugs that work in combination. However, this also means […]
Dear customers and partners, we are all part of a complex supply chain in a globalized world, with all its advantages and disadvantages. We are currently experiencing the rapid global spread of COVID-19 and would like to take responsibility as a supplier: most importantly, SiChem has taken all necessary preventive measures, e.g. home office where […]
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