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Fluorescent probes that react with complementary bioorthogonal reagents and subsequently light up are excellent tools for bioimaging applications. Vrabel et al. have synthesized a series of diverse coumarin-tetrazine probes that can react with SiChem’s TCOs and BCNs in seconds to act as labels in living cells. (SC-8106 / SC-8406) Juraj Galeta, et al.: A […]
Bremen is rather known as a trading city – less as a high-tech location for internationally operating biotech companies. But there are quite a few innovative, research-based companies that offer their products and services worldwide. Some of them are now presented by the Wirtschaftsförderung Bremen – SiChem is one of them ! Stories about Bremen […]
Alkyl diazirines are photo-reactive functional groups frequently used in photo-affinity labeling (PAL). They are compact in size, being nearly isosteric to a methyl group, and they are activated at a wavelength of light (~355 nm) that is not damaging to protein(s). Photo-crosslinked protein targets are then visualized by the reporter group (e.g. fluorophore, biotin, or […]
SiChem receives BMWi grant (ZIM) together with TU Clausthal for developing Smart Simulated Moving Bed Chromatography (sSMB) Personalised medicine is about treating patients as individually as possible. The drugs administered should have an optimal effect. Often, the patient is given precisely tailored treatment strategies with several drugs that work in combination. However, this also means […]
Dear customers and partners, we are all part of a complex supply chain in a globalized world, with all its advantages and disadvantages. We are currently experiencing the rapid global spread of COVID-19 and would like to take responsibility as a supplier: most importantly, SiChem has taken all necessary preventive measures, e.g. home office where […]
The conference will take place from 12th to 15th of December at the Oregeon Health and Science University (OHSU) in Portland, USA. This biennial international conference focuses on the growing intersection of chemical biology and physiology. This exciting field offers innovative opportunities for the development of drug targets and therapy concepts. Leading scientists from all […]
We will be at the CPhI in Frankfurt on November 6th and we still have available dates – if you like to meet us, just send us an e-mail and let us know when you will be available (info@sichem.de).
From Monday 21st to Tuesday 22nd October 2019 the Symposium of Noncanonical amino acids – Tools for biological and biophysical investigations will be held in Paris. It is co-organized with the French Peptides and Proteins Group (GFPP) This international symposium will focus on the emergent use of noncanonical amino acids (ncAAs) in peptide and protein science. […]
The trend in MALDI analysis today is towards large sample quantities, long scanning times and locally accurate measurement resolution. However, today’s MALDI matrices limit this progress for two reasons: First, they are not vacuum stable. As a result, the layer thickness changes during the time of a MALDI scan. This results in a loss of […]
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