Publications
2023
A Caged In-Source Laser-Cleavable MALDI Matrix with High Vacuum Stability for Extended MALDI-MS Imaging
Qiuqin Zhou, Stefano Rizzo, Janina Oetjen, Annabelle Fülöp, Miriam Rittner, Hartmut Gillandt, Carsten Hopf: // Angew. Chem. Int. Ed. 2023, e202217047 // https://doi.org/10.1002/anie.202217047
Structurally distinct PARP7 inhibitors provide new insights into the function of PARP7 in regulating nucleic acid-sensing and IFN-β signaling
Daniel J Sanderson , Kelsie M Rodrigue , Daniel S Bejan , Ninni E Olafsen , Inga D Bohn , Ana Kojic , Sunil Sundalam , Ivan R Siordia , Anna K Duell , Nancy Deng , Carsten Schultz , Denis M Grant , Jason Matthews , Michael S Cohen // Cell Chem Biol. 2023 Jan 19;30(1):43-54.e8.
doi: 10.1016/j.chembiol.2022.11.012
2022
A global lipid map reveals host dependency factors conserved across SARS-CoV-2 variants
Scotland E. Farley, Jennifer E. Kyle, Hans C. Leier , Lisa M. Bramer , Jules B. Weinstein ,Timothy A. Bates , Joon-Yong Lee, Thomas O. Metz , Carsten Schultz2 & Fikadu G. Tafesse // NATURE COMMUNICATIONS | (2022) 13:3487 | https://doi.org/10.1038/s41467-022-31097-7
“Flash & Click”: Multifunctionalized Lipid Derivatives as Tools To Study Viral Infections
Carsten Schultz, Scotland E. Farley, and Fikadu G. Tafesse // J. Am. Chem. Soc. 2022, 144, 13987−13995
ATP is an essential autocrine factor for pancreatic β-cell signaling and insulin secretion
Sebastian Hauke, Jona Rada, Gergely Tihanyi, Danny Schilling, Carsten Schultz // Physiol Rep 2022 Jan;10(1):e15159. doi: 10.14814/phy2.15159
Endosomal phosphatidylinositol 3-phosphate controls synaptic vesicle cycling and neurotransmissio
Guan Ting Liu, Gaga Kochlamazashvili, Dmytro Puchkov, Rainer Müller, Carsten Schultz, Albert I. Mackintosh, Dennis Vollweiter, Volker Haucke, Tolga Soykan // The EMBO Journal (2022)41:e109352https://doi.org/10.15252/embj.2021109352
Macrophage PD-1 associates with neutrophilia and reduced bacterial killing in early cystic fibrosis airway disease
Camilla Margaroli et al. // Journal of Cystic Fibrosis June 19, 2022DOI:https://doi.org/10.1016/j.jcf.2022.06.001
Membrane-Permeant, Bioactivatable Coumarin Derivatives for In-Cell Labelling
Madeleine Schultz, Rainer Müller, Yulia Ermakova, Jan Erik Hoffmann, Carsten Schultz //ChemBioChem https://doi.org/10.1002/cbic.202100699
2021
Caged lipids for subcellular manipulation
// Curr Opin Chem Biol. 2021 Dec;65:42-48. doi: 10.1016/j.cbpa.2021.04.012
Synthesis and Cellular Labeling of Multifunctional Phosphatidylinositol Bis- and Trisphosphate Derivatives
M// Angew Chem Int Ed Engl. 2021 Sep 1;60(36):19759-19765. doi: 10.1002/anie.202103599
2020
New Derivatization Reagent for Detection of free Thiol-groups in Metabolites and Proteins in Matrix-Assisted Laser Desorption/ Ionization Mass Spectrometry Imaging
Annabelle Fülöp,* Tobias Bausbacher, Stefano Rizzo, Qiuqin Zhou, Hartmut Gillandt, Carsten Hopf,
and Miriam Rittner // Anal. Chem. 2020, 92, 6224−6228 // https://dx.doi.org/10.1021/acs.analchem.9b05630
Photolysis of Caged Inositol Pyrophosphate InsP8 Directly Modulates Intracellular Ca2+ Oscillations and Controls C2AB Domain Localization
Optical Control of Lysophosphatidic Acid Signaling.
J Am Chem Soc. 2020 Jun 17;142(24):10612-10616. doi: 10.1021/jacs.0c02154. Epub 2020 Jun 5. PubMed PMID: 32469525; PubMed Central PMCID: PMC7920854.
ACLY is the novel signaling target of PIP2/PIP3 and Lyn in acute myeloid leukemia
Heliyon. 2020 May;6(5):e03910. doi: 10.1016/j.heliyon.2020.e03910. eCollection 2020 May. PubMed PMID: 32420483; PubMed Central PMCID: PMC7218026.
Phosphatidylinositol 3,4-bisphosphate synthesis and turnover are spatially segregated in the endocytic pathway
J Biol Chem. 2020 Jan 24;295(4):1091-1104. doi: 10.1074/jbc.RA119.011774. Epub 2019 Dec 12. PubMed PMID: 31831620; PubMed Central PMCID: PMC6983852
A Genetically Encoded Diazirine Analogue for RNA–Protein Photo-crosslinking
Dmytro Dziuba, Jan-Erik Hoffmann, Matthias W. Hentze, and Carsten Schultz(2020)
ChemBioChem 2020, 21, 88 – 93 doi.org/10.1002/cbic.201900559
2019
Cathepsin G Activity as a New Marker for Detecting Airway Inflammation by Microscopy and Flow Cytometry
Guerra M, Frey D, Hagner M, Dittrich S, Paulsen M, Mall MA, Schultz C. (2019)
ACS Cent Sci 5(3):539-548. doi: 10.1021/acscentsci.8b00933
Europe PMC | doi
Photolysis of cell-permeant caged inositol pyrophosphates controls oscillations of cytosolic calcium in a β-cell line
Hauke S, Dutta AK, Eisenbeis VB, Bezold D, Bittner T, Wittwer C, Thakor D, Pavlovic I, Schultz C, Jessen HJ. (2019)
Chem Sci 10(9):2687-2692. doi: 10.1039/c8sc03479f
Europe PMC | doi
Onset of differentiation is post-transcriptionally controlled in adult neural stem cells
Baser A, Skabkin M, Kleber S, Dang Y, Gülcüler Balta GS, Kalamakis G, Göpferich M, Ibañez DC, Schefzik R, Lopez AS, Bobadilla EL, Schultz C, Fischer B, Martin-Villalba A. (2019)
Nature 566(7742) doi: 10.1038/s41586-019-0888-x
Europe PMC | doi
2018
Optical tools for understanding the complexity of β-cell signalling and insulin release
Frank JA, Broichhagen J, Yushchenko DA, Trauner D, Schultz C, Hodson DJ. (2018)
Nat Rev Endocrinol 14(12):721-737. doi: 10.1038/s41574-018-0105-2
Europe PMC | doi
A Potent and Selective PARP11 Inhibitor Suggests Coupling between Cellular Localization and Catalytic Activity
Kirby IT, Kojic A, Arnold MR, Thorsell AG, Karlberg T, Vermehren-Schmaedick A, Sreenivasan R, Schultz C, Schüler H, Cohen MS. (2018)
Cell Chem Biol doi: 10.1016/j.chembiol.2018.09.011
Europe PMC | doi
Endogenous Fatty Acids are Essential Signaling Factors of Pancreatic β-Cells and Insulin Secretion
Hauke S, Keutler K, Phapale P, Yushchenko DA, Schultz C. (2018)
Diabetes doi: 10.2337/db17-1215
Europe PMC | doi
Neutrophil adhesion is a prerequisite for antibody-mediated proteolytic tissue damage in experimental epidermolysis bullosa acquisita
Yu X, Akbarzadeh R, Pieper M, Scholzen T, Gehrig S, Schultz C, Zillikens D, König P, Petersen F.(2018)
J Invest Dermatol doi: 10.1016/j.jid.2018.03.1499
Europe PMC | doi
Novel lipid tools and probes for biological investigations
Laguerre A, Schultz C. (2018)
Elife 6 doi: 10.7554/eLife.30203
Curr. Opin. Cell Biol. 53:97-104. doi: 10.1016/j.ceb.2018.06.013
Europe PMC | doi
A Bifunctional Noncanonical Amino Acid: Synthesis, Expression, and Residue-Specific Proteome-wide Incorporation
Hoffmann JE, Dziuba D, Stein F, Schultz C. (2018)
Biochemistry 57(31) doi: 10.1021/acs.biochem.8b00397
Europe PMC | doi
Endogenous Fatty Acids are Essential Signaling Factors of Pancreatic β-Cells and Insulin Secretion
Hauke S, Keutler K, Phapale P, Yushchenko DA, Schultz C. (2018)
Diabetes doi: 10.2337/db17-1215
Europe PMC | doi
PTEN suppresses axon outgrowth by down-regulating the level of detyrosinated microtubules
Kath C, Goni-Oliver P, Müller R, Schultz C, Haucke V, Eickholt B, Schmoranzer J. (2018)
PLoS One 13(4) doi: 10.1371/journal.pone.0193257
Europe PMC | doi
Elastase activity on sputum neutrophils correlates with severity of lung disease in cystic fibrosis
Dittrich AS, Kühbandner I, Gehrig S, Rickert-Zacharias V, Twigg M, Wege S, Taggart CC, Herth F, Schultz C, Mall MA. (2018)
Eur Respir J 51(3) doi: 10.1183/13993003.01910-2017
Europe PMC | doi
2017
Optical control of GPR40 signalling in pancreatic beta-cells
Frank JA, Yushchenko DA, Fine NHF, Duca M, Citir M, Broichhagen J, Hodson DJ, Schultz C, Trauner D. (2017)
CHEM SCI 8:7604-7610. doi: 10.1039/c7sc01475a
doi
Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis
Walter AM, Müller R, Tawfik B, Wierda KD, Pinheiro PS, Nadler A, McCarthy AW, Ziomkiewicz I, Kruse M, Reither G, Rettig J, Lehmann M, Haucke V, Hille B, Schultz C, Sorensen JB. (2017)
Elife 6 doi: 10.7554/eLife.30203
Europe PMC | doi
Local Generation and Imaging of Hydrogen Peroxide in Living Cells
Bogdanova YA, Schultz C, Belousov VV. (2017)
Curr Protoc Chem Biol 9(2):117-127. doi: 10.1002/cpch.20
Europe PMC | doi
mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate
Marat AL, Wallroth A, Lo WT, Müller R, Norata GD, Falasca M, Schultz C, Haucke V. (2017)
Science 356(6341):968-972. doi: 10.1126/science.aaf8310
Europe PMC | doi
Tetraspanin microdomains control localized protein kinase C signaling in B cells
Zuidscherwoude M, Dunlock VE, van den Bogaart G, van Deventer SJ, van der Schaaf A, van Oostrum J, Goedhart J, In ‘t Hout J, Hämmerling GJ, Tanaka S, Nadler A, Schultz C, Wright MD, Adjobo-Hermans MJW, van Spriel AB. (2017)
Sci Signal 10(478):1-15. doi: 10.1126/scisignal.aag2755
Europe PMC | doi
A Ratiometric Sensor for Imaging Insulin Secretion in Single β Cells
Schifferer M, Yushchenko DA, Stein F, Bolbat A, Schultz C. (2017)
Cell Chem Biol 525-531. doi: 10.1016/j.chembiol.2017.03.001
Europe PMC | doi
Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development
Bulusu V, Prior N, Snaebjornsson MT, Kuehne A, Sonnen KF, Kress J, Stein F, Schultz C, Sauer U, Aulehla A. (2017)
Dev. Cell 40(4):331-341. doi: 10.1016/j.devcel.2017.01.015
Europe PMC | doi
Trifunctional lipid probes for comprehensive studies of single lipid species in living cells
Höglinger D, Nadler A, Haberkant P, Kirkpatrick J, Schifferer M, Stein F, Hauke S, Porter FD, Schultz C. (2017)
Proc. Natl. Acad. Sci. U.S.A. 114(7):1566-1571. doi: 10.1073/pnas.1611096114
Europe PMC | doi
Endosomal Phosphatidylinositol-3-Phosphate Promotes Gephyrin Clustering and GABAergic Neurotransmission at Inhibitory Postsynapses
Papadopoulos T, Rhee HJ, Subramanian D, Paraskevopoulou F, Mueller R, Schultz C, Brose N, Rhee JS, Betz H. (2017)
J. Biol. Chem. 292(4):1160-1177. doi: 10.1074/jbc.M116.771592
Europe PMC | doi
Reversible Chemical Dimerization by rCD1
Schifferer M, Feng S, Stein F, Schultz C. (2017)
Meth. Enzymol. 583:173-195. doi: 10.1016/bs.mie.2016.10.035
Europe PMC | doi // this product could be interesting for you: SC-7000
2016
Yeast three-hybrid-Targetidentifizierung per Klick-Chemie
Stefano Rizzo, Rene Lang, Jacqueline Franke, Miriam Rittner
BIOSpektrum November 2016, Volume 22, Issue 7, pp 734–735. DOI: 10.1007/s12268-016-0752-6. http://rdcu.be/mCpy
Recent developments of genetically encoded optical sensors for cell biology
Bolbat A, Schultz C. (2016)
Biol. Cell doi: 10.1111/boc.201600040
Europe PMC | doi
A Protease Inhibitor Tackles Epithelial Sodium Channels in Cystic Fibrosis
Rickert-Zacharias V, Schultz C, Mall MA. (2016)
Am. J. Respir. Crit. Care Med. 194(6):650-652. doi: 10.1164/rccm.201604-0781ed
Lipid Discovery by Combinatorial Screening and Untargeted LC-MS/MS
Bilgin M, Born P, Fezza F, Heimes M, Mastrangelo N, Wagner N, Schultz C, Maccarrone M, Eaton S, Nadler A, Wilm M, Shevchenko A. (2016)
Sci Rep 6:27920. doi: 10.1038/srep27920
Europe PMC | doi
Optotaxis: Caged Lysophosphatidic Acid Enables Optical Control of a Chemotactic Gradient
Hövelmann F, Kedziora KM, Nadler A, Müller R, Jalink K, Schultz C. (2016)
Cell Chem Biol doi: 10.1016/j.chembiol.2015.11.019
Sphingosine-1-Phosphate Lyase Deficient Cells as a Tool to Study Protein Lipid Interactions
Gerl MJ, Bittl V, Kirchner S, Sachsenheimer T, Brunner HL, Lüchtenborg C, Özbalci C, Wiedemann H, Wegehingel S, Nickel W, Haberkant P, Schultz C, Krüger M, Brügger B. (2016)
PLoS ONE 11(4) doi: 10.1371/journal.pone.0153009
Europe PMC | doi
PI3K/AKT/mTOR-dependent stabilization of oncogenic far-upstream element binding proteins in hepatocellular carcinoma cells
Samarin J, Laketa V, Malz M, Roessler S, Stein I, Horwitz E, Singer S, Dimou E, Cigliano A, Bissinger M, Falk CS, Chen X, Dooley S, Pikarsky E, Calvisi DF, Schultz C, Schirmacher P, Breuhahn K. (2016)
Hepatology 63(3):813-826. doi: 10.1002/hep.28357
Cellular delivery and photochemical release of a caged inositol-pyrophosphate induces PH-domain translocation in cellulo
Pavlovic I, Thakor DT, Vargas JR, McKinlay CJ, Hauke S, Anstaett P, Camuña RC, Bigler L, Gasser G, Schultz C, Wender PA, Jessen HJ. (2016)
Nat Commun 7 doi: 10.1038/ncomms10622
A phosphoinositide conversion mechanism for exit from endosomes
Katharina Ketel, Michael Krauss, Anne-Sophie Nicot, Dmytro Puchkov, Marnix Wieffer, Rainer Müller, Devaraj Subramanian, Carsten Schultz, Jocelyn Laporte& Volker Haucke
Nature 529, 408–412 (21 January 2016); doi:10.1038/nature16516
2015
Highly Stable trans-Cyclooctene Amino Acids for Live-Cell Labeling
Hoffmann JE, Plass T, Nikić I, Aramburu IV, Koehler C, Gillandt H, Lemke EA, Schultz C.
Chem-Eur J 21(35):12266-12270. doi:10.1002/chem.201501647 these products could be interesting for you: SC-8008 (TCO*A)
Frontispiece: Highly Stable trans-Cyclooctene Amino Acids for Live-Cell Labeling
Hoffmann JE, Plass T, Nikić I, Aramburu IV, Koehler C, Gillandt H, Lemke EA, Schultz C.
Chemistry 21(35) doi:10.1002/chem.201583561
A single-cell model of PIP3 dynamics using chemical dimerization
MacNamara A, Stein F, Feng S, Schultz C, Saez-Rodriguez J.
Bioorg. Med. Chem. 2015, 23(12): 2868 / doi:10.1016/j.bmc.2015.04.074
Reversible chemical dimerizer-induced recovery of PIP2 levels moves clathrin to the plasma membrane
Schifferer M, Feng S, Stein F, Tischer C, Schultz C.
Bioorg. Med. Chem. 2015, 23 (12): 2862 / doi:10.1016/j.bmc.2015.03.048
Loss of atomic nitrogen from even-electron ions? A study on benzodiazepines
Axel Treu, Miriam Rittner, Dorit Kemken, Hans-Martin Schiebel, Peter Spiteller and Thomas Dülcks
J. Mass Spectrom. 2015, 50, 978–986
Covalent Divergent solid-phase synthesis of natural product-inspired bipartite cyclodepsipeptides - Total synthesis of seragamide A
H.-D. Arndt, S. Rizzo, C. Nöcker, V. N. Wakchaure, L.-G. Milroy, V. Bieker, A. Calderon, T. T. N. Tran, S. Brand, L. Dehmelt, H. Waldmann
Chem. Eur. J. 2015, accepted
