Click Chemistry

Inositol phosphates

Custom Synthesis

made by SiChem

Custom synthesis and Lifescience tools

Sirius Fine Chemicals SiChem GmbH synthesises active substances for the early phase/toxicology of drug development, mainly for the pharmaceutical industry.
Our special focus is on prodrugs, i.e. the active ingredient is initially inactive and is only released IN the organism.
This can be done, for example, by  endogenous enzymes.

A new approach is the release of the API (Active Pharmaceutical Ingredient) through a click reaction: here, the clickable inactive API is first transported to the site of action (e.g. to the tumour), where it reacts with a previously injected antibody or biopolymer that is also clickable.

SiChem also offers a wide range of useful tools, such as:

  • Si-CLICK®: click reagents, such as artificial amino acids, active esters, alkoxides, APIs…
  • Si-PEGs: functionalized PEG linkers for click chemistry or also for biotin and fluorescence labeling
  • Si-LIPs: functionalized Lipids and Derivatives
  • Si-DYEs: (clickable) Dyes with or without PEG-Linker (NEW!)
  • Inositol phosphates: free, membranepermeant and/or photoactivatable derivatives

Flash & Click:
powerful Tools for investigating
lipid signaling in live cells

NEmo: New FRET-based reporter system that detects NE activity – now available at Sichem

Direct linking of our products with
relevant publications
– with bioz

SiChem sponsors the “Chemical Biology and Physiology Conference 2023” in Portland

From 14-17 December, the "Chemical Biology and Physiology Conference 2023" will take place at Oregeon Health and Science University (OHSU) in Portland, USA. This international conference will focus on the ever-growing intersection of chemical…

TCO* for labelling neuronal compartments

Ivana Nikić-Spiegel et al. use Trans-Cyclooct-2-en-L-Lysine (TCO*; SC-8008) to label certain parts of neuronal compartments (axon initial segment (AIS)). Together with a clickable dye, these become visible under the microscope. The developed…

Vaccumstable MALDI-Matrices

Together with our cooperation partners from Mannheim University of Applied Sciences (HSM), we developed a completely new concept for vacuum-stable MALDI matrices. Now it’s published in “Angewandte Chemie” The trick is: we combined standard…