From October 14-15, the Chemical biology 2024 Conference will take place at Sorbonne University, Paris
From September 9-12, the Chemical biology 2024 Conference will take place at EMBL, Heidelberg
The conference provides a platform for the exchange of the latest developments in the field of chemical biology. As the largest and longest-standing conference in this field, it promotes inspiration, collaboration, and networking between researchers from academia and industry.
The aim is to give participants the opportunity to discuss topics such as the latest tools, biological applications, computational protein design, and new drug modalities.
From August 8-10, the 3rd GCE Conference will take place at Oregon State University (OSU) in Corvallis.
Over the past five years, GCE technology has developed rapidly, increasing interest in both academic and industrial fields.
SiChem is sponsoring the conference and the preceding workshop. With SiChem’s ncAAs, participants will learn more about encoding, selecting, and characterizing from OSU scientists firsthand, both in theory and practice.
The conference brings together developers and users to discuss technical advancements and attract new users. The goal is to promote the exchange of ideas and the formation of new networks.
From June 16th to 19th, 2024, the “Translational Bioimaging” symposium will take place in Würzburg at the Rudolf Virchow Center (RVZ).
This symposium will bring together established scientists, young researchers, and postdocs from around the world to discuss the latest developments and applications of genetic modifications (e.g., genetic code expansion), novel chemical reactions (e.g., bioorthogonal click chemistry), fluorescent probes, and microscopy for future biomedical applications >> bioimaging symposium 2024
From 14-17 December, the “Chemical Biology and Physiology Conference 2023” will take place at Oregeon Health and Science University (OHSU) in Portland, USA.
This international conference will focus on the ever-growing intersection of chemical biology and physiology. This exciting field offers innovative opportunities for the development of drug targets and therapeutic concepts. Leading scientists from all over the world will meet here to initiate, deepen and promote collaboration and collaboration and stimulate cutting-edge research.
Sponsors of Chemical Biology and Physiology Meeting 2023 OHSU
Ivana Nikić-Spiegel et al. use Trans-Cyclooct-2-en-L-Lysine (TCO*; SC-8008) to label certain parts of neuronal compartments (axon initial segment (AIS)). Together with a clickable dye, these become visible under the microscope. The developed method is particularly suitable for labelling complex and spatially limited proteins.
Journal of Cell Science (2023) 136: Direct fluorescent labeling of NF186 and NaV1.6 in living primary neurons using bioorthogonal click chemistry
Together with our cooperation partners from Mannheim University of Applied Sciences (HSM), we developed a completely new concept for vacuum-stable MALDI matrices.
Now it’s published in “Angewandte Chemie”
The trick is: we combined standard MALDI matrices with a caging group – this increases the vacuum stability. The caged group is then cleaved by the MALDI laser.
The vacuumstable MALDI-matrices are available at SiChem’s webshop: caged MALDI-Matrices
MSI (mouse brain) with vacuumstable MALDI-matrix measured after 0h and 72h
Chemistry Nobel Prize 2022 for Click Chemistry
Carolyn Bertozzi (Stanford University)
Morten Meldal (University of Copenhagen)
Barry Sharpless (Scripps Research Institute)
This year, the Nobel Prize in Chemistry was awarded to Carolyn Bertozzi of the University of Stanford, Morten Meldal of the University of Copenhagen, and Barry Sharpless of the Scripps Research Institute for their work on click chemistry and bioorthogonal reactions.
SiChem GmbH proudly offers a large number of reagents to perform click chemistry including several patented unnatural amino acids featuring strained double or triple bonds for incorporation into proteins and performing click chemistry inside cells and organisms. The Nobel committee mentioned the great use of click chemistry for preparing antibody-drug conjugates (ADCs). SiChem offers many of the click chemistry tools required for bringing this exciting technique to the patient. SiChem also synthesizes click reagents on a kg scale for selected cooperation partners.
Background: Click chemistry involves spontaneous irreversible reactions of two molecules to form a new chemical entity. What makes them so special is that these reactions can happen in a large variety of environments including water. This simple form of chemistry is therefore highly useful to many applications in material science, drug synthesis and even in intact organisms. Carolyn Bertozzi made these reactions independent of co-reagents and demonstrated the feasibility of applications in intact cells and organisms without detectable side-effects on the biology, coining to the reactions “bioorthogonal”.
SiChem congratulates the Nobel Prize winners for their impactful work.
SiChem supplies all 3 institutes with useful tools for click chemistry. Have a look at SiChem’s Click-Chemistry portfolio.
In Würzburg, experienced scientists and young researchers from all over the world come together to discuss the state of the art regarding the use of genetic modifications (e.g. genetic code expansion) for future biomedical treatments.
The Translational Bioimaging Symposium 2022
Here, bioorthogonal click chemistry plays a key role – SiChem offers a wide range of useful tools for this kind of chemical reactions.
Milan Vrabel et al. believe that performing abiotic chemical reactions within particular organelles at the subcellular level opens up new avenues: by manipulating biological processes in a targeted manner, they can be studied in more detail and this strategy can also be used to develop organelle-targeted drug-delivery systems. (TCO-NHS / SC-8070 / SC-8072 / SC-8073)
Rastislav Dzijak et al.: JACS Au 2021, 1, 23−30 : Structurally Redesigned Bioorthogonal Reagents for Mitochondria-Specific Prodrug Activation
