SiChem sponsors the Inositol Phosphate and Pyrophosphate Signalling Meeting 2026 in York

SiChem sponsors the Inositol Phosphate and Pyrophosphate Signalling Meeting 2026, taking place 13-15 October at the University of York, UK.

From October 13-15, 2026, the Inositol Phosphate and Pyrophosphate Signalling Meeting will take place at the University of York, UK.

SiChem is proud to sponsor this international meeting, which brings together leading researchers in the field of inositol phosphate signalling and its role in cellular processes.

More information and registration: Inositol Phosphate and Pyrophosphate Signalling Meeting 2026

SiChem: GMP ready

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Milestone: Click Chemistry in Cancer Therapy

A major advancement for bioorthogonal chemistry: For the first time, click chemistry has been successfully and safely applied in cancer therapy in humans. The so-called CAPAC® platform by Shasqi (Click Activated Protodrugs Against Cancer) enables the activation of an inactive doxorubicin prodrug directly within the tumor tissue – using a precise click reaction between a tetrazine-based polymer and a TCO-labeled drug.

The result: Significantly higher drug doses with reduced side effects, along with strong immune activation. A true milestone in oncology.
More information can be found in The Scientist.

SiChem sponsors the EMBL Chemical biology 2024 in Heidelberg

From September 9-12, the Chemical biology 2024 Conference will take place at EMBL, Heidelberg

The conference provides a platform for the exchange of the latest developments in the field of chemical biology. As the largest and longest-standing conference in this field, it promotes inspiration, collaboration, and networking between researchers from academia and industry.

The aim is to give participants the opportunity to discuss topics such as the latest tools, biological applications, computational protein design, and new drug modalities.

 

SiChem sponsors the GCE-Conference 2024 in Corvallis, USA

From August 8-10, the 3rd GCE Conference will take place at Oregon State University (OSU) in Corvallis.

Over the past five years, GCE technology has developed rapidly, increasing interest in both academic and industrial fields.

SiChem is sponsoring the conference and the preceding workshop. With SiChem’s ncAAs, participants will learn more about encoding, selecting, and characterizing from OSU scientists firsthand, both in theory and practice.

The conference brings together developers and users to discuss technical advancements and attract new users. The goal is to promote the exchange of ideas and the formation of new networks.

SiChem sponsors the “Translational Bioimaging Symposium 2024” in Würzburg

From June 16th to 19th, 2024, the  “Translational Bioimaging” symposium will take place in Würzburg at the Rudolf Virchow Center (RVZ).

This symposium will bring together established scientists, young researchers, and postdocs from around the world to discuss the latest developments and applications of genetic modifications (e.g., genetic code expansion), novel chemical reactions (e.g., bioorthogonal click chemistry), fluorescent probes, and microscopy for future biomedical applications >> bioimaging symposium 2024

translational bioimaging symposium Würzburg

SiChem sponsors the “Chemical Biology and Physiology Conference 2023” in Portland

From 14-17 December, the “Chemical Biology and Physiology Conference 2023” will take place at Oregeon Health and Science University (OHSU) in Portland, USA.

This international conference will focus on the ever-growing intersection of chemical biology and physiology. This exciting field offers innovative opportunities for the development of drug targets and therapeutic concepts. Leading scientists from all over the world will meet here to initiate, deepen and promote collaboration and collaboration and stimulate cutting-edge research.

Chemical Biology and Physiology 2023 OHSU

Sponsors of Chemical Biology and Physiology Meeting 2023 OHSU

TCO* for labelling neuronal compartments

Ivana Nikić-Spiegel et al. use Trans-Cyclooct-2-en-L-Lysine (TCO*; SC-8008) to label certain parts of neuronal compartments (axon initial segment (AIS)). Together with a clickable dye, these become visible under the microscope. The developed method is particularly suitable for labelling complex and spatially limited proteins.

Journal of Cell Science (2023) 136: Direct fluorescent labeling of NF186 and NaV1.6 in living primary neurons using bioorthogonal click chemistry

https://journals.biologists.com/jcs/article/136/12/jcs260600/320411/Direct-fluorescent-labeling-of-NF186-and-NaV1-6-in

Vaccumstable MALDI-Matrices

Together with our cooperation partners from Mannheim University of Applied Sciences (HSM), we developed a completely new concept for vacuum-stable MALDI matrices.
Now it’s published in “Angewandte Chemie”
The trick is: we combined standard MALDI matrices with a caging group – this increases the vacuum stability. The caged group is then cleaved by the MALDI laser.

The vacuumstable MALDI-matrices are available at SiChem’s webshop: caged MALDI-Matrices

MSI vom Maushirn: nach 72h noch brilliante Bilder

MSI (mouse brain) with vacuumstable MALDI-matrix measured after 0h and 72h