From 14-17 December, the “Chemical Biology and Physiology Conference 2023” will take place at Oregeon Health and Science University (OHSU) in Portland, USA.

This international conference will focus on the ever-growing intersection of chemical biology and physiology. This exciting field offers innovative opportunities for the development of drug targets and therapeutic concepts. Leading scientists from all over the world will meet here to initiate, deepen and promote collaboration and collaboration and stimulate cutting-edge research.

Chemical Biology and Physiology 2023 OHSU

Sponsors of Chemical Biology and Physiology Meeting 2023 OHSU

Ivana Nikić-Spiegel et al. use Trans-Cyclooct-2-en-L-Lysine (TCO*; SC-8008) to label certain parts of neuronal compartments (axon initial segment (AIS)). Together with a clickable dye, these become visible under the microscope. The developed method is particularly suitable for labelling complex and spatially limited proteins.

Journal of Cell Science (2023) 136: Direct fluorescent labeling of NF186 and NaV1.6 in living primary neurons using bioorthogonal click chemistry

Together with our cooperation partners from Mannheim University of Applied Sciences (HSM), we developed a completely new concept for vacuum-stable MALDI matrices.
Now it’s published in “Angewandte Chemie”
The trick is: we combined standard MALDI matrices with a caging group – this increases the vacuum stability. The caged group is then cleaved by the MALDI laser.

The vacuumstable MALDI-matrices are available at SiChem’s webshop: caged MALDI-Matrices

MSI vom Maushirn: nach 72h noch brilliante Bilder

MSI (mouse brain) with vacuumstable MALDI-matrix measured after 0h and 72h


Chemistry Nobel Prize 2022 for Click Chemistry

Carolyn Bertozzi (Stanford University)

Morten Meldal (University of Copenhagen)

Barry Sharpless (Scripps Research Institute)

This year, the Nobel Prize in Chemistry was awarded to Carolyn Bertozzi of the University of Stanford, Morten Meldal of the University of Copenhagen, and Barry Sharpless of the Scripps Research Institute for their work on click chemistry and bioorthogonal reactions.

SiChem GmbH proudly offers a large number of reagents to perform click chemistry including several patented unnatural amino acids featuring strained double or triple bonds for incorporation into proteins and performing click chemistry inside cells and organisms. The Nobel committee mentioned the great use of click chemistry for preparing antibody-drug conjugates (ADCs). SiChem offers many of the click chemistry tools required for bringing this exciting technique to the patient. SiChem also synthesizes click reagents on a kg scale for selected cooperation partners.

Background: Click chemistry involves spontaneous irreversible reactions of two molecules to form a new chemical entity. What makes them so special is that these reactions can happen in a large variety of environments including water. This simple form of chemistry is therefore highly useful to many applications in material science, drug synthesis and even in intact organisms. Carolyn Bertozzi made these reactions independent of co-reagents and demonstrated the feasibility of applications in intact cells and organisms without detectable side-effects on the biology, coining to the reactions “bioorthogonal”.

SiChem congratulates the Nobel Prize winners for their impactful work.

SiChem supplies all 3 institutes with useful tools for click chemistry. Have a look at SiChem’s Click-Chemistry portfolio.

In Würzburg, experienced scientists and young researchers from all over the world come together to discuss the state of the art regarding the use of genetic modifications (e.g. genetic code expansion) for future biomedical treatments.

The Translational Bioimaging Symposium 2022

Here, bioorthogonal click chemistry plays a key role – SiChem offers a wide range of useful tools for this kind of chemical reactions.

Click Chemistry Tools

Milan Vrabel et al. believe that performing abiotic chemical reactions within particular organelles at the subcellular level opens up new avenues: by manipulating biological processes in a targeted manner, they can be studied in more detail and this strategy can also be used to develop organelle-targeted drug-delivery systems. (TCO-NHS / SC-8070 / SC-8072 / SC-8073)

Rastislav Dzijak et al.: JACS Au 2021, 1, 23−30 : Structurally Redesigned Bioorthogonal Reagents for Mitochondria-Specific Prodrug Activation

Gerti Beliu et al. from the University of Würzburg use SiChem’s unnatural amino acid Trans-Cyclooct-2-en-L-Lysine (TCO*A; SC-8008 labelled with tetrazine dyes) for dSTORM experiments. A complete labelling and imaging pipeline has been developed to visualize transmembrane proteins in living neurons.

Diogo Bessa-Neto et al. : NATURE COMMUNICATIONS (2021) 12: 6715: Bioorthogonal labeling of transmembrane proteins with non-canonical amino acids unveils masked epitopes in live neurons

Neutrophils are often made responsible for killing bacteria in chronic diseases such as cystic fibrosis (CF). Here, however, there is an unexplained phenomenon: although neutrophils are massively present, long-lasting bacterial infections occur at the same time. Magaroli et al. from Emory University are trying to get to the bottom of this phenomenon and are also measuring the activity of free extracellular neutrophil elastase (NE) using SiChem’s FRET-based NEmo-1 probes (SC-0200 / SC-0201).


Fluorescent probes that react with complementary bioorthogonal reagents and subsequently light up are excellent tools for bioimaging applications.

Vrabel et al. have synthesized a series of diverse coumarin-tetrazine probes that can react with SiChem’s TCOs and BCNs in seconds to act as labels in living cells. (SC-8106 / SC-8406)


Juraj Galeta, et al.: A Systematic Study of Coumarin–Tetrazine Light-Up Probes for Bioorthogonal Fluorescence Imaging

Chem. Eur. J. 2020, 26, 9945 – 9953

Bremen is rather known as a trading city – less as a high-tech location for internationally operating biotech companies. But there are quite a few innovative, research-based companies that offer their products and services worldwide. Some of them are now presented by the Wirtschaftsförderung Bremen – SiChem is one of them ! Stories about Bremen Business