The trend in MALDI analysis today is towards large sample quantities, long scanning times and locally accurate measurement resolution. However, today’s MALDI matrices limit this progress for two reasons:
First, they are not vacuum stable. As a result, the layer thickness changes during the time of a MALDI scan. This results in a loss of sensitivity, a signal drift and thus considerable measurement errors.
Second: Co-crystals with HCCA, 2.5-DHAP or 2.5-DHB usually exceed the size of 10µm, which is why higher resolutions are not possible. The aim of the project is the development of new vacuum-stable matrices, which form homogeneous co-crystal layer thicknesses over 24h with possible analytes such as peptides, proteins, lipids and active substances.

The aim of the project is the development of a new process for targeted and position-specific immobilization of enzymes on carrier materials. The immobilization of enzymes increases their stability and the possibility of reusability and allows catalytic steps to run more effectively and with higher turnover. The project will run for 36 months and has a volume of more than 500TEUR.

SiChem congratulates the Nobel Laureates in Chemistry Frances H. Arnold (California Institute of Technology / Caltech), George P. Smith (University of Missouri), and Gregory Winter (MRC Laboratory of Molecular Biology). Smith (University of Missouri), and Gregory Winter (MRC Laboratory of Molecular Biology). SiChem provides all 3 institutes with its useful tools for biochemical research.

SiChem sponsors with pre4U this year’s SPICA – the 17th International Symposium for Preparative and Industrial Chromatography.

SiChem supports the Tübingen team at the “international Genetically Engineered Machine” (iGEM) competition. More than 300 teams from all over the world take part in this renowned competition in the field of synthetic biology. They present their results to an international jury in Boston (iGEM).