The trend in MALDI analysis today is towards large sample quantities, long scanning times and locally accurate measurement resolution. However, today’s MALDI matrices limit this progress for two reasons:
First, they are not vacuum stable. As a result, the layer thickness changes during the time of a MALDI scan. This results in a loss of sensitivity, a signal drift and thus considerable measurement errors.
Second: Co-crystals with HCCA, 2.5-DHAP or 2.5-DHB usually exceed the size of 10µm, which is why higher resolutions are not possible. The aim of the project is the development of new vacuum-stable matrices, which form homogeneous co-crystal layer thicknesses over 24h with possible analytes such as peptides, proteins, lipids and active substances.