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SiChem sponsors the “Chemical Biology and Physiology Conference 2023” in Portland

From 14-17 December, the “Chemical Biology and Physiology Conference 2023” will take place at Oregeon Health and Science University (OHSU) in Portland, USA. This international conference will focus on the ever-growing intersection of chemical biology and physiology. This exciting field offers innovative opportunities for the development of drug targets and therapeutic concepts. Leading scientists from […]

Flash & Click – Powerful tools for investigating lipid signaling in live cells

In order to study identity, function, location, transport and interacting proteins of lipids, trifunctional lipid (TFL) derivatives provide the ideal tool to answer your research questions. The combination of three functional groups allows for excellent temporal control of lipid release through uncaging, protect from wash-out in fixed samples and covalent connections to binding proteins through […]

TCO* for labelling neuronal compartments

Ivana Nikić-Spiegel et al. use Trans-Cyclooct-2-en-L-Lysine (TCO*; SC-8008) to label certain parts of neuronal compartments (axon initial segment (AIS)). Together with a clickable dye, these become visible under the microscope. The developed method is particularly suitable for labelling complex and spatially limited proteins. Journal of Cell Science (2023) 136: Direct fluorescent labeling of NF186 and […]

Vaccumstable MALDI-Matrices

Together with our cooperation partners from Mannheim University of Applied Sciences (HSM), we developed a completely new concept for vacuum-stable MALDI matrices. Now it’s published in “Angewandte Chemie” The trick is: we combined standard MALDI matrices with a caging group – this increases the vacuum stability. The caged group is then cleaved by the MALDI […]

SiChem congratulates this year’s Nobel Prize winners in Chemistry

Carolyn Bertozzi (Stanford University) Morten Meldal (University of Copenhagen) Barry Sharpless (Scripps Research Institute) This year, the Nobel Prize in Chemistry was awarded to Carolyn Bertozzi of the University of Stanford, Morten Meldal of the University of Copenhagen, and Barry Sharpless of the Scripps Research Institute for their work on click chemistry and bioorthogonal reactions. […]

TCO-active ester as drug-delivery system

Milan Vrabel et al. believe that performing abiotic chemical reactions within particular organelles at the subcellular level opens up new avenues: by manipulating biological processes in a targeted manner, they can be studied in more detail and this strategy can also be used to develop organelle-targeted drug-delivery systems. (TCO-NHS / SC-8070 / SC-8072 / SC-8073) […]

TCO* for single-molecule super-resolution imaging

Gerti Beliu et al. from the University of Würzburg use SiChem’s unnatural amino acid Trans-Cyclooct-2-en-L-Lysine (TCO*A; SC-8008 labelled with tetrazine dyes) for dSTORM experiments. A complete labelling and imaging pipeline has been developed to visualize transmembrane proteins in living neurons. Diogo Bessa-Neto et al. : NATURE COMMUNICATIONS (2021) 12: 6715: Bioorthogonal labeling of transmembrane proteins with […]

NEmo explains unexplained phenomenon

Neutrophils are often made responsible for killing bacteria in chronic diseases such as cystic fibrosis (CF). Here, however, there is an unexplained phenomenon: although neutrophils are massively present, long-lasting bacterial infections occur at the same time. Magaroli et al. from Emory University are trying to get to the bottom of this phenomenon and are also […]