Neutrophils are often made responsible for killing bacteria in chronic diseases such as cystic fibrosis (CF). Here, however, there is an unexplained phenomenon: although neutrophils are massively present, long-lasting bacterial infections occur at the same time. Magaroli et al. from Emory University are trying to get to the bottom of this phenomenon and are also measuring the activity of free extracellular neutrophil elastase (NE) using SiChem’s FRET-based NEmo-1 probes (SC-0200 / SC-0201).
Margaroli et al., 2021, Cell Reports Medicine 2, 100239: Transcriptional firing represses bactericidal activityin cystic fibrosis airway neutrophils