Click Chemistry

Inositol phosphates

Custom Synthesis

made by SiChem

Custom synthesis and Lifescience tools

Sirius Fine Chemicals SiChem GmbH synthesizes APIs for early stage (Toxicology) drug design. A special field of expertise is the preparation of biologically and pharmacologically active compounds with increased bioavailability (prodrugs).

We are one of the leading providers for inositol phosphates as well as a large variety of membranepermeant and photoactivatable derivatives. Our portfolio has been supplemented by clickable unnatural amino acids and other useful tools for Click-Chemistry.

NEW: tools with PEG-linkers: here you will find a large selection of tools with different length PEG-linkers. These are suitable for click-chemistry-reactions or for biotin- and fluorescence- labelling.

Click-Photocrosslinking compounds

Click-Photocrosslinking compounds for photo-affinity labeling (PAL)

 

NEmo: New FRET-based reporter system that detects NE activity – now available at Sichem

Rapidly reversible Chemical Dimerizer rCD1 is now available at SiChem

TCO* for single-molecule super-resolution imaging

Gerti Beliu et al. from the University of Würzburg use SiChem's unnatural amino acid Trans-Cyclooct-2-en-L-Lysine (TCO*A; SC-8008 labelled with tetrazine dyes) for dSTORM experiments. A complete labelling and imaging pipeline has been developed…

NEmo explains unexplained phenomenon

Neutrophils are often made responsible for killing bacteria in chronic diseases such as cystic fibrosis (CF). Here, however, there is an unexplained phenomenon: although neutrophils are massively present, long-lasting bacterial infections occur…

BCN-PEG-NHS / TCO-PEG-NHS for bioimaging

Fluorescent probes that react with complementary bioorthogonal reagents and subsequently light up are excellent tools for bioimaging applications. Vrabel et al. have synthesized a series of diverse coumarin-tetrazine probes that can react…