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Click Chemistry

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Inositol phosphates

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Custom Synthesis

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made by SiChem

Custom synthesis and Lifescience tools

Sirius Fine Chemicals SiChem GmbH synthesizes APIs for early stage (Toxicology) drug design. A special field of expertise is the preparation of biologically and pharmacologically active compounds with increased bioavailability (prodrugs).

We are one of the leading providers for inositol phosphates as well as a large variety of membranepermeant and photoactivatable derivatives. Our portfolio has been supplemented by clickable unnatural amino acids and other useful tools for Click-Chemistry.

NEW: tools with PEG-linkers: here you will find a large selection of tools with different length PEG-linkers. These are suitable for click-chemistry-reactions or for biotin- and fluorescence- labelling.

Click-Photocrosslinking compounds

Click-Photocrosslinking compounds for photo-affinity labeling (PAL)

 

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NEmo: New FRET-based reporter system that detects NE activity – now available at Sichem

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Rapidly reversible Chemical Dimerizer rCD1 is now available at SiChem

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SiChem sponsors the “Translational Bioimaging RVZ Symposium” in Würzburg (18-20th of September 2022)

In Würzburg, experienced scientists and young researchers from all over the world come together to discuss the state of the art regarding the use of genetic modifications (e.g. genetic code expansion) for future biomedical treatments. The…
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TCO-active ester as drug-delivery system

Milan Vrabel et al. believe that performing abiotic chemical reactions within particular organelles at the subcellular level opens up new avenues: by manipulating biological processes in a targeted manner, they can be studied in more detail…
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TCO* for single-molecule super-resolution imaging

Gerti Beliu et al. from the University of Würzburg use SiChem's unnatural amino acid Trans-Cyclooct-2-en-L-Lysine (TCO*A; SC-8008 labelled with tetrazine dyes) for dSTORM experiments. A complete labelling and imaging pipeline has been developed…
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