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Click Chemistry

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Inositol phosphates

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Custom Synthesis

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made by SiChem

Custom synthesis and Lifescience tools

Sirius Fine Chemicals SiChem GmbH synthesizes APIs for early stage (Toxicology) drug design. A special field of expertise is the preparation of biologically and pharmacologically active compounds with increased bioavailability (prodrugs).

We are one of the leading providers for inositol phosphates as well as a large variety of membranepermeant and photoactivatable derivatives. Our portfolio has been supplemented by clickable unnatural amino acids and other useful tools for Click-Chemistry.

NEW: tools with PEG-linkers: here you will find a large selection of tools with different length PEG-linkers. These are suitable for click-chemistry-reactions or for biotin- and fluorescence- labelling.

Click-Photocrosslinking compounds

Click-Photocrosslinking compounds for photo-affinity labeling (PAL)

 

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NEmo: New FRET-based reporter system that detects NE activity – now available at Sichem

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Rapidly reversible Chemical Dimerizer rCD1 is now available at SiChem

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TCO-active ester as drug-delivery system

Milan Vrabel et al. believe that performing abiotic chemical reactions within particular organelles at the subcellular level opens up new avenues: by manipulating biological processes in a targeted manner, they can be studied in more detail…
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TCO* for single-molecule super-resolution imaging

Gerti Beliu et al. from the University of Würzburg use SiChem's unnatural amino acid Trans-Cyclooct-2-en-L-Lysine (TCO*A; SC-8008 labelled with tetrazine dyes) for dSTORM experiments. A complete labelling and imaging pipeline has been developed…
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NEmo explains unexplained phenomenon

Neutrophils are often made responsible for killing bacteria in chronic diseases such as cystic fibrosis (CF). Here, however, there is an unexplained phenomenon: although neutrophils are massively present, long-lasting bacterial infections occur…
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