Publications

2017

Local Generation and Imaging of Hydrogen Peroxide in Living Cells.
Bogdanova YA, Schultz C, Belousov VV. (2017)
Curr Protoc Chem Biol 9(2):117-127. doi: 10.1002/cpch.20
Europe PMC | doi

mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate.
Marat AL, Wallroth A, Lo WT, Müller R, Norata GD, Falasca M, Schultz C, Haucke V. (2017)
Science 356(6341):968-972. doi: 10.1126/science.aaf8310
Europe PMC | doi

Tetraspanin microdomains control localized protein kinase C signaling in B cells.
Zuidscherwoude M, Dunlock VE, van den Bogaart G, van Deventer SJ, van der Schaaf A, van Oostrum J, Goedhart J, In 't Hout J, Hämmerling GJ, Tanaka S, Nadler A, Schultz C, Wright MD, Adjobo-Hermans MJW, van Spriel AB. (2017)
Sci Signal 10(478):1-15. doi: 10.1126/scisignal.aag2755
Europe PMC | doi

A Ratiometric Sensor for Imaging Insulin Secretion in Single β Cells.
Schifferer M, Yushchenko DA, Stein F, Bolbat A, Schultz C. (2017)
Cell Chem Biol 525-531. doi: 10.1016/j.chembiol.2017.03.001
Europe PMC | doi

Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development
Bulusu V, Prior N, Snaebjornsson MT, Kuehne A, Sonnen KF, Kress J, Stein F, Schultz C, Sauer U, Aulehla A. (2017)
Dev. Cell 40(4):331-341. doi: 10.1016/j.devcel.2017.01.015
Europe PMC | doi

Trifunctional lipid probes for comprehensive studies of single lipid species in living cells.
Höglinger D, Nadler A, Haberkant P, Kirkpatrick J, Schifferer M, Stein F, Hauke S, Porter FD, Schultz C. (2017)
Proc. Natl. Acad. Sci. U.S.A. 114(7):1566-1571. doi: 10.1073/pnas.1611096114
Europe PMC | doi

Endosomal Phosphatidylinositol-3-Phosphate Promotes Gephyrin Clustering and GABAergic Neurotransmission at Inhibitory Postsynapses.
Papadopoulos T, Rhee HJ, Subramanian D, Paraskevopoulou F, Mueller R, Schultz C, Brose N, Rhee JS, Betz H. (2017)
J. Biol. Chem. 292(4):1160-1177. doi: 10.1074/jbc.M116.771592
Europe PMC | doi

Reversible Chemical Dimerization by rCD1.
Schifferer M, Feng S, Stein F, Schultz C. (2017)
Meth. Enzymol. 583:173-195. doi: 10.1016/bs.mie.2016.10.035
Europe PMC | doi //  this product could be interesting for you: SC-7000

 

2016

Yeast three-hybrid-Targetidentifizierung per Klick-Chemie
Stefano Rizzo, Rene Lang, Jacqueline Franke, Miriam Rittner
BIOSpektrum , Volume 22, Issue 7, pp 734–735.  DOI: 10.1007/s12268-016-0752-6. http://rdcu.be/mCpy

Recent developments of genetically encoded optical sensors for cell biology.
Bolbat A, Schultz C. (2016)
Biol. Cell doi: 10.1111/boc.201600040 Europe PMC | doi
 
A Protease Inhibitor Tackles Epithelial Sodium Channels in Cystic Fibrosis.
Rickert-Zacharias V, Schultz C, Mall MA. (2016)
Am. J. Respir. Crit. Care Med. 194(6):650-652. doi: 10.1164/rccm.201604-0781ed  Europe PMC | doi
 
Lipid Discovery by Combinatorial Screening and Untargeted LC-MS/MS.
Bilgin M, Born P, Fezza F, Heimes M, Mastrangelo N, Wagner N, Schultz C, Maccarrone M, Eaton S, Nadler A, Wilm M, Shevchenko A. (2016) 
Sci Rep 6:27920. doi: 10.1038/srep27920 Europe PMC | doi

Optotaxis: Caged Lysophosphatidic Acid Enables Optical Control of a Chemotactic Gradient.
Hövelmann F, Kedziora KM, Nadler A, Müller R, Jalink K, Schultz C. (2016)
Cell Chem Biol doi: 10.1016/j.chembiol.2015.11.019 Europe PMC | doi

Sphingosine-1-Phosphate Lyase Deficient Cells as a Tool to Study Protein Lipid Interactions.
Gerl MJ, Bittl V, Kirchner S, Sachsenheimer T, Brunner HL, Lüchtenborg C, Özbalci C, Wiedemann H, Wegehingel S, Nickel W, Haberkant P, Schultz C, Krüger M, Brügger B. (2016)
PLoS ONE
11(4) doi: 10.1371/journal.pone.0153009 Europe PMC | doi

PI3K/AKT/mTOR-dependent stabilization of oncogenic far-upstream element binding proteins in hepatocellular carcinoma cells.
Samarin J, Laketa V, Malz M, Roessler S, Stein I, Horwitz E, Singer S, Dimou E, Cigliano A, Bissinger M, Falk CS, Chen X, Dooley S, Pikarsky E, Calvisi DF, Schultz C, Schirmacher P, Breuhahn K. (2016)
Hepatology
63(3):813-826. doi: 10.1002/hep.28357

Cellular delivery and photochemical release of a caged inositol-pyrophosphate induces PH-domain translocation in cellulo.
Pavlovic I, Thakor DT, Vargas JR, McKinlay CJ, Hauke S, Anstaett P, Camuña RC, Bigler L, Gasser G, Schultz C, Wender PA, Jessen HJ. (2016)
Nat Commun
7 doi: 10.1038/ncomms10622

A phosphoinositide conversion mechanism for exit from endosomes
Katharina Ketel, Michael Krauss, Anne-Sophie Nicot, Dmytro Puchkov, Marnix Wieffer, Rainer Müller, Devaraj Subramanian, Carsten Schultz, Jocelyn Laporte& Volker Haucke
Nature
529, 408–412 (21 January 2016); doi:10.1038/nature16516

2015

Highly Stable trans-Cyclooctene Amino Acids for Live-Cell Labeling
Hoffmann JE, Plass T, Nikić I, Aramburu IV, Koehler C, Gillandt H, Lemke EA, Schultz C.
Chem-Eur J 21(35):12266-12270. doi:10.1002/chem.201501647    these products could be interesting for you: SC-8008 (TCO*A)

Frontispiece: Highly Stable trans-Cyclooctene Amino Acids for Live-Cell Labeling.
Hoffmann JE, Plass T, Nikić I, Aramburu IV, Koehler C, Gillandt H, Lemke EA, Schultz C.
Chemistry
21(35) doi:10.1002/chem.201583561    these products could be interesting for you: SC-8008 (TCO*A)

A single-cell model of PIP3 dynamics using chemical dimerization
MacNamara A, Stein F, Feng S, Schultz C, Saez-Rodriguez J.
Bioorg. Med. Chem. 2015, 23(12): 2868 / doi:10.1016/j.bmc.2015.04.074   this product could be interesting for you: SC-7000

Reversible chemical dimerizer-induced recovery of PIP2 levels moves clathrin to the plasma membrane
Schifferer M, Feng S, Stein F, Tischer C, Schultz C.
Bioorg. Med. Chem. 2015, 23 (12): 2862 / doi:10.1016/j.bmc.2015.03.048   this product could be interesting for you: SC-7000

Loss of atomic nitrogen from even-electron ions? A study on benzodiazepines
Axel Treu, Miriam Rittner, Dorit Kemken, Hans-Martin Schiebel, Peter Spiteller and Thomas Dülcks
J. Mass Spectrom. 2015, 50, 978–986 

Covalent Divergent solid-phase synthesis of natural product-inspired bipartite cyclodepsipeptides - Total synthesis of seragamide A
H.-D. Arndt, S. Rizzo, C. Nöcker, V. N. Wakchaure, L.-G. Milroy, V. Bieker, A. Calderon, T. T. N. Tran, S. Brand, L. Dehmelt, H. Waldmann
Chem. Eur. J. 2015, accepted

 

 

2009 - 2014

 

2014

 

Airway mucus obstruction triggers macrophage activation and matrix metalloproteinase 12-dependent emphysema
Trojanek JB, Cobos-Correa A, Diemer S, Kormann M, Schubert SC, Zhou-Suckow Z, Agrawal R, Duerr J, Wagner CJ, Schatterny J, Hirtz S, Sommerburg O, Hartl D, Schultz C, Mall MA. (2014)
Am. J. Respir. Cell Mol. Biol. 51(5):709-720. doi:10.1165/rcmb.2013-0407oc.
Europe PMC | doi    this product could be interesting for you: SC-0043

 

A New Player in the Game: Epithelial Cathepsin S in Early Cystic Fibrosis Lung Disease
Mall MA, Schultz C. (2014)
Am. J. Resp. Crit. Care 190(2):126-127. doi:10.1164/rccm.201405-0935ED
. Europe PMC | doi

 

T-CrAsH: A Heterologous Chemical Crosslinker.
Rutkowska, A., Plass, T., Hoffmann, J.E., Yushchenko, D.A., Feng, S. & Schultz, C.
Chembiochem. 2014 Jul 10. doi: 10.1002/cbic.201402189. Europe PMC    these products could be interesting for you: SC-8008 (TCO*A)  SC-8014 (endo-BCN) SC-8016 (exo-BCN) 

 

The European Molecular Biology Laboratory (EMBL)-Its Anniversary and Its Chemistry.
Schultz, C.
Angew Chem Int Ed Engl. 2014 Jul 7. doi: 10.1002/anie.201405106. Europe PMC

 

In Vivo Imaging of Mouse Tumors by a Lipidated Cathepsin S Substrate.
Hu, H.Y., Vats, D., Vizovisek, M., Kramer, L., Germanier, C., Wendt, K.U., Rudin, M., Turk, B., Plettenburg, O. & Schultz, C.
Angew Chem Int Ed Engl. 2014 May 30. doi: 10.1002/anie.201310979. Europe PMC

 

A Rapidly Reversible Chemical Dimerizer System to Study Lipid Signaling in Living Cells.
Feng, S., Laketa, V., Stein, F., Rutkowska, A., MacNamara, A., Depner, S., Klingmuller, U., Saez-Rodriguez, J. & Schultz, C.
Angew Chem Int Ed Engl. 2014 May 19. doi: 10.1002/anie.201402294. Europe PMC     this product could be interesting for you: SC-7000

 

Plasma membrane phosphoinositide balance regulates cell shape during Drosophila embryo morphogenesis.
Reversi, A., Loeser, E., Subramanian, D., Schultz, C. & De Renzis, S.
J Cell Biol. 2014 May 12;205(3):395-408. doi: 10.1083/jcb.201309079. Epub 2014May 5. Europe PMC

 

Caged lipids as tools for investigating cellular signaling.
Hoglinger, D., Nadler, A. & Schultz, C.
This is a review article.
Biochim Biophys Acta. 2014 Apr 5. pii: S1388-1981(14)00065-1. doi:10.1016/j.bbalip.2014.03.012. Europe PMC

 

Lack of neutrophil elastase reduces inflammation, mucus hypersecretion and emphysema, but not mucus obstruction, in mice with CF-like lung disease.
Gehrig, S., Duerr, J., Weitnauer, M., Wagner, C.J., Graeber, S.Y., Schatterny, J., Hirtz, S., Belaaouaj, A., Dalpke, A.H., Schultz, C. & Mall, M.A.
Am J Respir Crit Care Med. 2014 Mar 28. Europe PMC

 

Genetically encoded fluorescent indicator for imaging NAD/NADH ratio changes in different cellular compartments.
Bilan, D.S., Matlashov, M.E., Gorokhovatsky, A.Y., Schultz, C., Enikolopov, G. & Belousov, V.V.
Biochim Biophys Acta. 2014;1840(3):951-957. doi:10.1016/j.bbagen.2013.11.018. Epub 2013 Nov 25. Europe PMC

 

Minimal Tags for Rapid Dual-Color Live-Cell Labeling and Super-Resolution Microscopy.
Nikic, I., Plass, T., Schraidt, O., Szymanski, J., Briggs, J.A., Schultz, C. & Lemke, E.A.
Angew Chem Int Ed Engl. 2014 Jan 28; 53 (8): 2245. doi: 10.1002/anie.201309847. Europe PMC     these products could be interesting for you: SC-8008 (TCO*A)  SC-8014 (endo-BCN) SC-8016 (exo-BCN) SC-8000 (SCO)

 

FRET-based and other fluorescent proteinase probes.
Hu, H.Y., Gehrig, S., Reither, G., Subramanian, D., Mall, M.A., Plettenburg, O. & Schultz, C.
Biotechnol J. 2014 Jan 27. doi: 10.1002/biot.201300201. Europe PMC

 

PIP3 Induces the Recycling of Receptor Tyrosine Kinases.
Laketa, V., Zarbakhsh, S., Traynor-Kaplan, A., Macnamara, A., Subramanian, D., Putyrski, M., Mueller, R., Nadler, A., Mentel, M., Saez-Rodriguez, J., Pepperkok, R. & Schultz, C.
Sci Signal. 2014 Jan 14;7(308):ra5. doi: 10.1126/scisignal.2004532. Europe PMC

 

Fluorogenic probes for live-cell imaging of the cytoskeleton
G. Lukinavičius, L. Reymond, E. d'Este, A. Masharina, F. Göttfert, H. Ta, A. Güther, M. Fournier, S. Rizzo, H. Waldmann, C. Blaukopf, C. Sommer, D. W. Gerlich, H.-D. Arndt, S. W. Hell, K. Johnsson, Nat. Methods 2014, 11, 731-733.

 

Development of a Natural Product-Derived Chemical Toolbox for Modulation of Protein Function
S. Rizzo, H. Waldmann
Chem. Rev.
2014, 114, 4621-4639

 

 

 

2013

 

Tissue Clearing for Optical Anatomy. Yushchenko, D.A. & Schultz, C.
Angew Chem Int Ed Engl. 2013 Sep 3. doi: 10.1002/anie.201306039. Europe PMC

 

Chemical Activators of Protein Phosphatase-1 Induce Calcium Release inside Intact Cells. Reither, G., Chatterjee, J., Beullens, M., Bollen, M., Schultz, C. & Köhn, M.
Chem Biol. 2013 Aug 20. pii: S1074-5521(13)00275-5. doi:10.1016/j.chembiol.2013.07.008. Europe PMC     this product could be interesting for you: SC-0100

 

FluoQ: A Tool for Rapid Analysis of Multiparameter Fluorescence Imaging Data Applied to Oscillatory Events. Stein, F., Kress, M., Reither, S., Piljic, A. & Schultz, C.
ACS Chem Biol. 2013 Aug 6. Europe PMC

 

In Vivo profiling and visualization of cellular protein-lipid interactions using bifunctional Fatty acids. Haberkant, P., Raijmakers, R., Wildwater, M., Sachsenheimer, T., Brugger, B., Maeda, K., Houweling, M., Gavin, A.C., Schultz, C., van Meer, G., Heck, A.J. & Holthuis, J.C.
Angew Chem Int Ed Engl. 2013 Apr 2;52(14):4033-8. doi: 10.1002/anie.201210178.Epub 2013 Feb 28. Europe PMC

 

The power of fluorogenic probes. Nadler, A. & Schultz, C.
Angew Chem Int Ed Engl. 2013 Feb 25;52(9):2408-10. doi: 10.1002/anie.201209733.Epub 2013 Jan 21. Europe PMC

 

A near-infrared fluorophore for live-cell super-resolution microscopy of cellular proteins. Lukinavicius, G., Umezawa, K., Olivier, N., Honigmann, A., Yang, G., Plass, T., Mueller, V., Reymond, L., Correa IR, J.r, Luo, Z.G., Schultz, C., Lemke, E.A., Heppenstall, P., Eggeling, C., Manley, S. & Johnsson, K.
Nat Chem. 2013 Feb;5(2):132-9. doi: 10.1038/nchem.1546. Epub 2013 Jan 6. Europe PMC

 

HyPer-3: A Genetically Encoded H2O2 Probe with Improved Performance for Ratiometric and Fluorescence Lifetime Imaging. Bilan, D.S., Pase, L., Joosen, L., Gorokhovatsky, A.Y., Ermakova, Y.G., Gadella, T.W., Grabher, C., Schultz, C., Lukyanov, S. & Belousov, V.V.
ACS Chem Biol. 2013 Mar 15;8(3):535-42. doi: 10.1021/cb300625g. Epub 2013 Jan 7. Europe PMC

 

The Fatty Acid composition of diacylglycerols determines local signaling patterns. Nadler, A., Reither, G., Feng, S., Stein, F., Reither, S., Muller, R. & Schultz, C.
Angew Chem Int Ed Engl. 2013 Jun 10;52(24):6330-4. doi: 10.1002/anie.201301716.Epub 2013 May 29. Europe PMC

 

 

 

2012

 

Genetic encoding of a bicyclo[6.1.0]nonyne-charged amino acid enables fast cellular protein imaging by metal-free ligation. Borrmann, A., Milles, S., Plass, T., Dommerholt, J., Verkade, J.M., Wiessler, M., Schultz, C., van Hest, J.C., van Delft, F.L. & Lemke, E.A.
Chembiochem. 2012 Sep 24;13(14):2094-9. doi: 10.1002/cbic.201200407. Epub 2012Sep 3. Europe PMC

 

The chemical biology of phosphoinositide 3-kinases. Wymann, M.P. & Schultz, C.
Chembiochem. 2012 Sep 24;13(14):2022-35. doi: 10.1002/cbic.201200089. Epub 2012Sep 10. Europe PMC

 

Protein tango: the toolbox to capture interacting partners. Rutkowska, A. & Schultz, C.
Angew Chem Int Ed Engl. 2012 Aug 13;51(33):8166-76. doi: 10.1002/anie.201201717.Epub 2012 Jun 11. Europe PMC

 

Target-activated prodrugs for the auto-regulated inhibition of MMP12. Cobos-Correa, A., Stein, F., Schultz, C.
ACS Med. Chem. Lett., 2012, 3 (8), pp 653-657, doi: 10.1021/ml3001193.

 

Control of TMEM16A by INO-4995 and other inositolphosphates
Yuemin Tian, Rainer Schreiber, Podchanart Wanitchakool, Patthara Kongsuphol, Marisa Sousa, Inna Uliyakina, Marta Palma, Diana Faria, Alexis E. Traynor-Kaplen, José I. Fragata, Margarida D. Amaral, Karl Kunzelmann

British Journal of Pharmacology 2013, 168(1): 253-65

 

Can We See PIP(3) and Hydrogen Peroxide with a Single Probe?
Mishina, N.M., Bogeski, I., Bolotin, D.A., Hoth, M., Niemeyer, B.A., Schultz, C., Zagaynova, E.V., Lukyanov, S. & Belousov, V.V.
Antioxid Redox Signal. 2012 Aug 1;17(3):505-12. Epub 2012 Apr 10. PubMed

 

Genetically encoded copper-free click chemistry. Plass, T., Milles, S., Koehler, C., Schultz, C. & Lemke, E.A.
Angew Chem Int Ed Engl. 2011 Apr 18;50(17):3878-81. doi:10.1002/anie.201008178. Epub 2011 Mar 23. Europe PMC

 

Conformational Analysis of a Genetically Encoded FRET Biosensor by SAXS.
Mertens, H.D., Piljic, A., Schultz, C. & Svergun, D.I.
Biophys J. 2012 Jun 20;102(12):2866-75. Epub 2012 Jun 19. PubMed

 

Spatially resolved monitoring of neutrophil elastase activity with ratiometric fluorescent reporters.
Gehrig, S., Mall, M.A. & Schultz, C.
Angew Chem Int Ed Engl. 2012 Jun 18;51(25):6258-61. doi: 10.1002/anie.201109226.Epub 2012 May 3. PubMed

 

Protein Tango: The Toolbox to Capture Interacting Partners.
Rutkowska, A. & Schultz, C.
Angew Chem Int Ed Engl. 2012 Jun 11. doi: 10.1002/anie.201201717. PubMed

 

Protein translocation as a tool: The current rapamycin story.
Putyrski, M. & Schultz, C.
FEBS Lett. 2012 May 11. PubMed

 

A novel method for spatially complex diffraction-limited photoactivation and photobleaching in living cells
Vyacheslav M. Shkryl, Joshua T. Maxwell and Lothar A. Blatter:
J Physiol 590.5 (2012) pp 1093–1100

 

Amino acids for diels-alder reactions in living cells.
Plass, T., Milles, S., Koehler, C., Szymanski, J., Mueller, R., Wiessler, M., Schultz, C. & Lemke, E.A.
Angew Chem Int Ed Engl. 2012 Apr 23;51(17):4166-70. doi: 10.1002/anie.201108231.Epub 2012 Mar 30. PubMed

 

Interactions of phytate and myo-inositol phosphate esters (IP1-5) including IP5 somers with dietary protein and iron and inhibition of pepsin
S. Yu, A. Cowieson, C. Gilbert, P. Plumstead and S. Dalsgaard
J ANIM SCI 2012, 90:1824-1832

 

 

 

2011

 

A FlAsH-Based Cross-Linker to Study Protein Interactions in Living Cells.
Rutkowska, A., Haering, C.H. & Schultz, C.
Angew Chem Int Ed Engl. 2011 Dec 23;50(52):12655-8. doi:10.1002/anie.201106404. Epub 2011 Nov 16. PubMed

 

Switching heterotrimeric G protein subunits with a chemical dimerizer.
Putyrski, M. & Schultz, C.
Chem Biol. 2011 Sep 23;18(9):1126-33. PubMed

 

Principles for designing fluorescent sensors and reporters.
Lemke, E.A. & Schultz, C.
Nat Chem Biol. 2011 Jul 18;7(8):480-3. doi: 10.1038/nchembio.620. PubMed

 

Rapid development of genetically encoded FRET reporters.
Piljic, A., de Diego, I., Wilmanns, M. & Schultz, C.
ACS Chem Biol. 2011 Jul 15;6(7):685-91. Epub 2011 Apr 28. PubMed

 

The ENaC-overexpressing mouse as a model of cystic fibrosis lung disease.
Zhou, Z., Duerr, J., Johannesson, B., Schubert, S.C., Treis, D., Harm, M., Graeber, S.Y., Dalpke, A., Schultz, C. & Mall, M.A.
J Cyst Fibros. 2011 Jun;10 Suppl 2:S172-82. PubMed

 

Genetically encoded copper-free click chemistry.
Plass, T., Milles, S., Koehler, C., Schultz, C. & Lemke, E.A.
Angew Chem Int Ed Engl. 2011 Apr 18;50(17):3878-81. doi:10.1002/anie.201008178. Epub 2011 Mar 23.
PubMed

 

Photoactivatable and cell-membrane-permeable phosphatidylinositol 3,4,5-trisphosphate.
Mentel, M., Laketa, V., Subramanian, D., Gillandt, H. & Schultz, C.
Angew Chem Int Ed Engl. 2011 Apr 11;50(16):3811-4. doi:10.1002/anie.201007796. Epub 2011 Mar 14.
PubMed

 

Imaging probes--Introduction.
Schultz, C. & Aime, S.
Bioorg Med Chem. 2011 Feb 1;19(3):1022.
PubMed

 

Does cellular hydrogen peroxide diffuse or act locally?
Mishina, N.M., Tyurin-Kuzmin, P.A., Markvicheva, K.N., Vorotnikov, A.V., Tkachuk, V.A., Laketa, V., Schultz, C., Lukyanov, S. & Belousov, V.V.
Antioxid Redox Signal. 2011 Jan 1;14(1):1-7. Epub 2010 Oct 12.
PubMed

 

Inositol pentakisphosphate isomers bind PH domains with varying specificity and inhibit phosphoinositide interactions.
Jackson, S.G., Al-Saigh, S., Schultz, C. & Junop, M.S.
BMC Struct Biol. 2011 Feb 10;11:11.
PubMed

 

 

 

2010

 

Airway surface liquid volume regulation determines different airway phenotypes in liddle compared with betaENaC-overexpressing mice.
Mall, M.A., Button, B., Johannesson, B., Zhou, Z., Livraghi, A., Caldwell, R.A., Schubert, S.C., Schultz, C., O'Neal, W.K., Pradervand, S., Hummler, E., Rossier, B.C., Grubb, B.R. & Boucher, R.C.
J Biol Chem. 2010 Aug 27;285(35):26945-55. Epub 2010 Jun 21.
PubMed

 

Challenges in studying phospholipid signaling.
Schultz, C.
Nat Chem Biol. 2010 Jul;6(7):473-5.
PubMed

 

Activation of membrane-permeant caged PtdIns(3)P induces endosomal fusion in cells.
Subramanian, D.*, Laketa, V.*, Muller, R., Tischer, C., Zarbakhsh, S., Pepperkok, R. & Schultz, C. * - equally contributing first authors.
Nat Chem Biol. 2010 May;6(5):324-6. Epub 2010 Apr 4.
PubMed

 

The ßENaC-overexpressing mouse as a model of cystic fibrosis lung disease.
Zhou, Z., Duerr, J., Johannesson, B., Schubert, S. C., Treis, D., Harm, M., Gräber, S., Dalpke, A., Schultz, C., Mall, M. A.
J. Cystic Fibr. (2010)

 

Imaging lipids in living cells.
Schultz, C., Neef, A., Goedhart, J. & Gadella, T.W.J.
In 'Live Cell Imaging', Spector, D.L., Svedlow, J. & Jaron, B.F (eds), 2010, Cold Spring Harbor Press

 

INO-4995 therapeutic efficacy is enhanced with repeat dosing in cystic fibrosis knockout mice and human epithelia
Traynor-Kaplan AE, Moody M, Nur M, Gabriel S, Majerus PW, Drumm ML, Langton-Webster B.
Am J Respir Cell Mol Biol. 2010 Jan;42(1):105-12

 

 

Membrane-permeant phosphoinositide derivatives as modulators of growth factor signaling and neurite outgrowth.
Laketa, V., Zarbakhsh, S., Morbier, E., Subramanian, D., Dinkel, C., Brumbaugh, J., Zimmermann, P., Pepperkok, R. & Schultz, C.
Chem Biol. 2009 Nov 25;16(11):1190-6.
PubMed

Membrane-bound FRET probe visualizes MMP12 activity in pulmonary inflammation.
Cobos-Correa, A., Trojanek, J.B., Diemer, S., Mall, M.A. & Schultz, C.
Nat Chem Biol. 2009 Sep;5(9):628-30. Epub 2009 Aug 2.
PubMed

Fluorescent revelations.
Schultz, C.
Chem Biol. 2009 Feb 27;16(2):107-11.
PubMed

Chemical biologists gather in Heidelberg.
Köhn, M. & Schultz, C.
Nat Chem Biol. 2009 Feb;5(2):66-9.
PubMed

Selective fluorescence labeling of lipids in living cells.
Neef, A.B. & Schultz, C.
Angew Chem Int Ed Engl. 2009;48(8):1498-500.
PubMed

 

2000 - 2008

Analysis of protein complex hierarchy in living cells.
Piljic, A. & Schultz, C.
ACS Chem Biol. 2008 Dec 19;3(12):749-55.
PubMed

Contribution of fluorophores to protein kinase C FRET probe performance.
Jost, C.A., Reither, G., Hoffmann, C. & Schultz, C.
Chembiochem. 2008 Jun 16;9(9):1379-84.
PubMed

Simultaneous recording of multiple cellular events by FRET.
Piljic, A. & Schultz, C.
ACS Chem Biol. 2008 Mar 20;3(3):156-60.
PubMed

Heterogeneity and timing of translocation and membrane-mediated assembly of different annexins.
Skrahina, T., Piljic, A. & Schultz, C.
Exp Cell Res. 2008 Mar 10;314(5):1039-47. Epub 2007 Nov 29.
PubMed

Fluorescence and bioluminescence procedures for functional proteomics.
Prinz, A., Reither, G., Diskar, M. & Schultz, C.
Proteomics. 2008 Mar;8(6):1179-96.
PubMed

Versatile application of trifluoromethyl triflate
Alexander A. Kolomeitsev, Mikhail Vorobyev, Hartmut Gillandt

Tetrahedron Letters 2008, 49: 449

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Probing lipid- and drug-binding domains with fluorescent dyes
Black, S.L., Stanley, W.A., Filipp, F.V., Bhairo, M., Verma, A., Wichmann, O., Sattler, M., Wilmanns, M. & Schultz, C.

Bioorg Med Chem. 2008

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Live-Cell Imaging of Enzyme-Substrate Interaction Reveals Spatial Regulation of PTP1B
Ivan A. Yudushkin, Andreas Schleifenbaum, Ali Kinkhabwala, Benjamin G. Neel, Carsten Schultz, Philippe I. H. Bastiaen
Science 2007; 315: 115
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Probing Phospholipase A2 with Fluorescent Phospholipid Substrates
Oliver Wichmann,Michael H. Gelb,and Carsten Schultz

ChemBioChem 2007, 8: 1555

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Investigation of the ligand spectrum of human sterol carrier protein 2 using a direct mass spectrometry assay
Will A. Stanley, Kees Versluis, Carsten Schultz, Albert J.R. Heck, Matthias Wilmanns

Arch. Biochem and Biophys. 2007, 461: 50

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Calcium-dependent regulation of NF-nB activation in cystic fibrosis airway epithelial cells
Olivier Tabary, Emilie Boncoeur, Rainer de Martin, Rainer Pepperkok, Annick Cle´ment, Carsten Schultz, Jacky Jacquot

Cellular Signalling 2006, 18: 652

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Advances in analysis and synthesis of myo-inositol-derivatives through resolution by crystallisation
Wolfgang Wewers, Hartmut Gillandtb,and Henner Schmidt Traub

Tetrahedron Asymmetry 2005, 16: 1723

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Antagonists of myo-Inositol 3,4,5,6-Tetrakisphosphate Allow Repeated Epithelial Chloride Secretion
Marco T. Rudolf,Carlo Dinkel, Alexis E. Traynor-Kaplan and Carsten Schultz

Bioorganic & Medicinal Chemistry 11, 2003: 3315

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Prodrugs of Biologically Active Phosphate Esters
Carsten Schultz

Bioorganic & Medicinal Chemistry 11, 2003: 885

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Membrane-Permeant 3-OH-Phosphorylated Phosphoinositide Derivatives
Carlo Dinkel, Mark Moody, Alexis Traynor-Kaplan, and Carsten Schultz

Angew. Chem. Int. Ed. 2001, 40, 16: 3004

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myo-Inositol 3,4,5,6-Tetrakisphosphate Inhibits an Apical Calcium-activated Chloride Conductance in Polarized Monolayers of a Cystic Fibrosis Cell Line
Mark A. Carew, Xiaonian Yang, Carsten Schultz, and Stephen B. Shears

J. Biol. Chem. 2000, 275, 35: 26906

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1993 - 1998

2-Deoxy Derivative Is a Partial Agonist of the Intracellular Messenger Inositol 3,4,5,6-Tetrakisphosphate in the Epithelial Cell Line T84
Marco T. Rudolf, Wen-hong Li, Nora Wolfson, Alexis E. Traynor-Kaplan, and Carsten Schultz

J. Med. Chem. 1998, 41: 3635

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Membrane-permeant esters of inositol polyphosphates: chemical syntheses and biological applications
Li, W., Schultz, C., Llopis, J., and Tsien, R.Y. 1997

Tetrahedron 1997, 53: 12017-12040

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D-myo-Inositol 1,4,5,6-tetrakisphosphate produced in human intestinal epithelial cells in response to Salmonella invasion inhibits phosphoinositide 3-kinase signaling pathways
Lars Eckmann, Marco T. Rudolf, Andrzej Ptasnznik, Carsten Schultz, Tao Jiang, Nora Wolfson, Roger Tsien, Joshua Fierer, Stephen B. Shears, Martin F. Kagnoff, Alexis E. Traynor-Kaplan

Proc. Natl. Acad. Sci. USA 1997, 94: 14456

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Cross-talk between calcium and cAMP-dependent intracellular signalling pathways: implications for synergistic secretion in T84 colonic epithelial cells and rat pancreatic acinar cells
Vajanaphanich, M., Schultz, C., Tsien, R.Y., Traynor-Kaplan, A.E., Pandol, S.J. and Barrett, K.E.

J. Clin. Invest. 1995, 96: 386-393

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Long-term uncoupling of chloride secretion from intracellular calcium levels by Ins(3,4,5,6)P4
Vajanaphanich, M., Schultz, C., Rudolf, M.T., Wasserman, M., Enyedi, P., Craxton, A., Shears, S.B., Tsien, R.Y. Barrett, K.E., and Traynor-Kaplan, A.

Nature 1994, 371: 711-714

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Membrane-permeant derivatives of cyclic AMP optimized for high potency, prolonged activity, or rapid reversibility
Schultz, C., Vajanaphanich, M., Genieser, H.G., Jastorff, B., Barrett, K.E., and Tsien, R.Y.

Mol. Pharmacol. 1994, 46: 702-708

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Acetoxymethyl esters of phosphates: enhancement of the permeability and potency of cAMP
Schultz, C., Vajanaphanich, M., Harootunian, A.T., Sammak, P.J., Barrett, K.E., and Tsien, R.Y.

J. Biol. Chem. 1993, 268: 6316-6322

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