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TCO* for labelling neuronal compartments

Ivana Nikić-Spiegel et al. use Trans-Cyclooct-2-en-L-Lysine (TCO*; SC-8008) to label certain parts of neuronal compartments (axon initial segment (AIS)). Together with a clickable dye, these become visible under the microscope. The developed…
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BIOZ com

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Vaccumstable MALDI-Matrices

Together with our cooperation partners from Mannheim University of Applied Sciences (HSM), we developed a completely new concept for vacuum-stable MALDI matrices. Now it’s published in “Angewandte Chemie” The trick is: we combined standard…
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SiChem congratulates this year’s Nobel Prize winners in Chemistry

Carolyn Bertozzi (Stanford University) Morten Meldal (University of Copenhagen) Barry Sharpless (Scripps Research Institute) This year, the Nobel Prize in Chemistry was awarded to Carolyn Bertozzi of the University of Stanford,…
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SiChem sponsors the “Translational Bioimaging RVZ Symposium” in Würzburg (18-20th of September 2022)

In Würzburg, experienced scientists and young researchers from all over the world come together to discuss the state of the art regarding the use of genetic modifications (e.g. genetic code expansion) for future biomedical treatments. The…
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TCO-active ester as drug-delivery system

Milan Vrabel et al. believe that performing abiotic chemical reactions within particular organelles at the subcellular level opens up new avenues: by manipulating biological processes in a targeted manner, they can be studied in more detail…
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