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SiChem congratulates this year’s Nobel Prize winners in Chemistry

Carolyn Bertozzi (Stanford University) Morten Meldal (University of Copenhagen) Barry Sharpless (Scripps Research Institute) This year, the Nobel Prize in Chemistry was awarded to Carolyn Bertozzi of the University of Stanford,…

SiChem sponsors the “Translational Bioimaging RVZ Symposium” in Würzburg (18-20th of September 2022)

In Würzburg, experienced scientists and young researchers from all over the world come together to discuss the state of the art regarding the use of genetic modifications (e.g. genetic code expansion) for future biomedical treatments. The…

TCO-active ester as drug-delivery system

Milan Vrabel et al. believe that performing abiotic chemical reactions within particular organelles at the subcellular level opens up new avenues: by manipulating biological processes in a targeted manner, they can be studied in more detail…

TCO* for single-molecule super-resolution imaging

Gerti Beliu et al. from the University of Würzburg use SiChem's unnatural amino acid Trans-Cyclooct-2-en-L-Lysine (TCO*A; SC-8008 labelled with tetrazine dyes) for dSTORM experiments. A complete labelling and imaging pipeline has been developed…

NEmo explains unexplained phenomenon

Neutrophils are often made responsible for killing bacteria in chronic diseases such as cystic fibrosis (CF). Here, however, there is an unexplained phenomenon: although neutrophils are massively present, long-lasting bacterial infections occur…

BCN-PEG-NHS / TCO-PEG-NHS for bioimaging

Fluorescent probes that react with complementary bioorthogonal reagents and subsequently light up are excellent tools for bioimaging applications. Vrabel et al. have synthesized a series of diverse coumarin-tetrazine probes that can react…