Sirius Fine Chemicals SiChem GmbH synthesises active substances for the early phase/toxicology of drug development, mainly for the pharmaceutical industry.
Our special focus is on prodrugs, i.e. the active ingredient is initially inactive and is only released IN the organism.
This can be done, for example, by endogenous enzymes.
A new approach is the release of the API (Active Pharmaceutical Ingredient) through a click reaction: here, the clickable inactive API is first transported to the site of action (e.g. to the tumour), where it reacts with a previously injected antibody or biopolymer that is also clickable.
SiChem also offers a wide range of useful tools, such as:
- Inositol phosphates: free, membranepermeant and/or photoactivatable derivatives
- Si-CLICK : click reagents, such as artificial amino acids, active esters, alkoxides, APIs…
- Si-PEGs: functionalized PEG linkers for click chemistry or also for biotin and fluorescence labeling