Custom synthesis and Lifescience tools made by SiChem

Sirius Fine Chemicals SiChem GmbH synthesizes APIs for early stage (Toxicology) drug design. A special field of expertise is the preparation of biologically and pharmacologically active compounds with increased bioavailability (prodrugs).

We are one of the leading providers for inositol phosphates as well as a large variety of membranepermeant and photoactivatable derivatives. Our portfolio has been supplemented by clickable unnatural amino acids and other useful tools for Click-Chemistry.

NEW:  tools with PEG-linkers: here you will find a large selection of tools with different length PEG-linkers. These are suitable for click-chemistry-reactions or for biotin- and fluorescence- labelling.


SiChem sponsors the iGEM Team
SiChem supports the Bielefeld team in the "international Genetically Engineered Machine" (iGEM) competition. More than 300 teams from all over the world take part in this prestigious synthetic biology contest. They present their results to an international jury in Boston.

iGEM Team Bilefeld

 


 

New : PHYCOCYANOBILIN (PCB)   SC-1800

PCB is the essential chromophore of the PhyB-PIF optogenetic system. This allows to control protein localisation subcellularly

”SiChem’s PCB is working marvelously”  says Dr. Alba Diz-Muñoz, Group Leader, EMBL

 Phycocyanobilin SC-1800

 

 

 

 

 

 

 

 

 

 

 

Buckley et al., 2016, Developmental Cell 36,
117–126 January 11, 2016
http://dx.doi.org/10.1016/j.devcel.2015.12.011

 

 

 


SiChem - member of the i3 - Life Sciences Cluster - is a " Landmark in the Land of Ideas"

The competition " 100 Landmarks in the Land of Ideas" promotes ideas for urgent issues of tomorrow.  The i3 - Life Sciences Cluster tries to find answers to the increasing life expectancy and the associated diseases. Innovative diagnostic companies in the Bremen / Bremerhaven region have joined forces to investigate biomarkers that may indicate certain diseases more accurately.

100Ideen_an


INO-4995 has potential in treatment of Cystic Fibrosis (CF)

 INO-4995 (1-O-octyl-2-O-butyryl-D-myo-inositol 3,4,5,6-tetrakisphosphate octakis(propionoxymethyl)ester) is an ion channel modulator that is slowly metabolized in cells. Studies have shown that it inhibits ENaC activity while promoting expression of the calcium-activated chloride channel, TMEM16a, in membranes. Thus it has potential therapeutic activity in the treatment of cystic fibrosis where it normalized nasal potential difference (npd) in a murine CF knock-out model and promoted fluid secretion in human CF airway epithelia.

Strong preclinical efficacy of INO-4995: a membrane-permeant Inositol-phosphate derivative has potential in treatment of Cystic Fibrosis (CF)
This graph is showing the difference in npd between mice before and after 4-day treatment with INO-4995 (0.0008mg/kg): 
Am J Respir Cell Mol Biol 2010, 42(1), 105

INO-4995 in mice model

Interested in INO-4995?


 

PDP3: New Tool to study the biology of Protein Phosphatase-1 (PP1)

SiChem expanded its portfolio toward peptides: PP1-Disrupting Peptides (PDPs) can be used as selective tools to study acute and long-term effects of PP1 activation in intact cells. This membrane-permeant peptide competes with endogenous, the motif RVxF containing PIPs to bind to PP1 in living cells. This PDP3 does not bind to the closely related phosphatase PP2A.

In addition, PDPs can be used to sensitize cells for clinically relevant kinase inhibitors (SC-0100)

 



Rapidly reversible Chemical Dimerizer rCD1 is now available at SiChem

The first rapidly reversible chemical dimerization system – rCD1 - , which permits to determine kinetics of lipid metabolizing enzymes in living cells, is now available at SiChem . This new system was applied to induce and stop the activity of phosphatidyl 3-kinase (PI3K) (product information) rCD1 is available in 2 sizes: 100µg (for app. 20 experiments) and 500µg (SC-7000)

Chemical Dimerizer SiChem

 

Chemical Dimerizer rCD1

A representative time-lapse fluorescence movie of HeLa cells co-transfected 
with NLS2-SNAPf-ECFP and mRFP-FKBP constructs. rCD1 (1 μM) induces 
translocation of mRFP-FKBP into the nucleus; addition of FK506 (1 μM) leads to 
release of mRFP-FKBP from the nucleus !

 


New Click-Amino Acids for In Vivo Protein Labeling - now available at SiChem !

There is a growing demand in advanced fluorescence microscopy for small and highly photostable fluorescent probes. These probes consists of unnatural clickable Amino Acids (UAAs) which can be  labeled in vivo with a clickable dye. The corresponding click-Amino Acids are now available at SiChem.

SCo TCOstar 

Insulin Receptors - expressed with two unnatural amino acids (UAAs) TCO*A (SC-8008)  and SCO (SC-8000) labeled with Cy5-CH3-Tetrazin (cyan) und Atto532-H-Tetrazin (magenta)
(Nikic et al. Angew. Chem. Int. Ed. 2014, 53 (8): 2245)