Click Chemistry

Inositol phosphates

Custom Synthesis

made by SiChem

Custom synthesis and Lifescience tools

Sirius Fine Chemicals SiChem GmbH synthesises active substances for the early phase/toxicology of drug development, mainly for the pharmaceutical industry.
Our special focus is on prodrugs, i.e. the active ingredient is initially inactive and is only released IN the organism.
This can be done, for example, by  endogenous enzymes.

A new approach is the release of the API (Active Pharmaceutical Ingredient) through a click reaction: here, the clickable inactive API is first transported to the site of action (e.g. to the tumour), where it reacts with a previously injected antibody or biopolymer that is also clickable.

SiChem also offers a wide range of useful tools, such as:

  • Si-CLICK : click reagents, such as artificial amino acids, active esters, alkoxides, APIs…
  • Si-PEGs: functionalized PEG linkers for click chemistry or also for biotin and fluorescence labeling
  • Si-LIPs: functionalized Lipids and Derivatives
  • Inositol phosphates: free, membranepermeant and/or photoactivatable derivatives
Click-Photocrosslinking compounds

Click-Photocrosslinking compounds
for photo-affinity labeling

NEmo: New FRET-based reporter system that detects NE activity – now available at Sichem

Direct linking of our products with
relevant publications
– with bioz

Vaccumstable MALDI-Matrices

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SiChem congratulates this year’s Nobel Prize winners in Chemistry

Carolyn Bertozzi (Stanford University) Morten Meldal (University of Copenhagen) Barry Sharpless (Scripps Research Institute) This year, the Nobel Prize in Chemistry was awarded to Carolyn Bertozzi of the University of Stanford,…

SiChem sponsors the “Translational Bioimaging RVZ Symposium” in Würzburg (18-20th of September 2022)

In Würzburg, experienced scientists and young researchers from all over the world come together to discuss the state of the art regarding the use of genetic modifications (e.g. genetic code expansion) for future biomedical treatments. The…