SiChem GmbH - Custom synthesis - Enantioseparation

Versatile application of trifluoromethyl triflate

Alexander A. Kolomeitsev, Mikhail Vorobyev, Hartmut Gillandt
Tetrahedron Letters 2008, 49: 449
Download: PDF file, 168 KB

Probing lipid- and drug-binding domains with fluorescent dyes

Black, S.L., Stanley, W.A., Filipp, F.V., Bhairo, M., Verma, A., Wichmann, O., Sattler, M., Wilmanns, M. & Schultz, C.
Bioorg Med Chem. 2008 (in press)
Download: PDF file, 951 KB

Live-Cell Imaging of Enzyme-Substrate Interaction Reveals Spatial Regulation of PTP1B

Ivan A. Yudushkin, Andreas Schleifenbaum, Ali Kinkhabwala, Benjamin G. Neel, Carsten Schultz, Philippe I. H. Bastiaens
Science 2007; 315: 115
Download: PDF file, 338 KB

Probing Phospholipase A2 with Fluorescent Phospholipid Substrates

Oliver Wichmann,Michael H. Gelb,and Carsten Schultz
ChemBioChem 2007, 8: 1555
Download: PDF file, 574 KB

Investigation of the ligand spectrum of human sterol carrier protein 2 using a direct mass spectrometry assay

Will A. Stanley, Kees Versluis, Carsten Schultz, Albert J.R. Heck, Matthias Wilmanns
Arch. Biochem and Biophys. 2007, 461: 50
Download: PDF file, 1.048 KB

Calcium-dependent regulation of NF-nB activation in cystic fibrosis airway epithelial cells

Olivier Tabary, Emilie Boncoeur, Rainer de Martin, Rainer Pepperkok, Annick Cle´ment, Carsten Schultz, Jacky Jacquot
Cellular Signalling 2006, 18: 652
Download: PDF file, 464 KB

Advances in analysis and synthesis of myo-inositol-derivatives through resolution by crystallisation

Wolfgang Wewers, Hartmut Gillandtb,and Henner Schmidt Traub
Tetrahedron Asymmetry 2005, 16: 1723
Download: PDF file, 171 KB

Antagonists of myo-Inositol 3,4,5,6-Tetrakisphosphate Allow Repeated Epithelial Chloride Secretion

Marco T. Rudolf,Carlo Dinkel, Alexis E. Traynor-Kaplan and Carsten Schultz
Bioorganic & Medicinal Chemistry 11, 2003: 3315
Download: PDF file, 481 KB

Prodrugs of Biologically Active Phosphate Esters

Carsten Schultz
Bioorganic & Medicinal Chemistry 11, 2003: 885
Download: PDF file, 345 KB

Membrane-Permeant 3-OH-Phosphorylated Phosphoinositide Derivatives

Carlo Dinkel, Mark Moody, Alexis Traynor-Kaplan, and Carsten Schultz
Angew. Chem. Int. Ed. 2001, 40, 16: 3004
Download: PDF file, 133 KB

myo-Inositol 3,4,5,6-Tetrakisphosphate Inhibits an Apical Calcium-activated Chloride Conductance in Polarized Monolayers of a Cystic Fibrosis Cell Line

Mark A. Carew, Xiaonian Yang, Carsten Schultz, and Stephen B. Shears
J. Biol. Chem. 2000, 275, 35: 26906
Download: PDF file, 312 KB

2-Deoxy Derivative Is a Partial Agonist of the Intracellular Messenger Inositol 3,4,5,6-Tetrakisphosphate in the Epithelial Cell Line T84

Marco T. Rudolf, Wen-hong Li, Nora Wolfson, Alexis E. Traynor-Kaplan, and Carsten Schultz
J. Med. Chem. 1998, 41: 3635
Download: PDF file, 204 KB

Membrane-permeant esters of inositol polyphosphates: chemical syntheses and biological applications

Li, W., Schultz, C., Llopis, J., and Tsien, R.Y. 1997
Tetrahedron 1997, 53: 12017-12040
Download: PDF file, 1.020 KB

D-myo-Inositol 1,4,5,6-tetrakisphosphate produced in human intestinal epithelial cells in response to Salmonella invasion inhibits phosphoinositide 3-kinase signaling pathways

Lars Eckmann, Marco T. Rudolf, Andrzej Ptasnznik, Carsten Schultz, Tao Jiang, Nora Wolfson, Roger Tsien, Joshua Fierer, Stephen B. Shears, Martin F. Kagnoff, Alexis E. Traynor-Kaplan
Proc. Natl. Acad. Sci. USA 1997, 94: 14456
Download: PDF file, 561 KB

Cross-talk between calcium and cAMP-dependent intracellular signalling pathways: implications for synergistic secretion in T84 colonic epithelial cells and rat pancreatic acinar cells

Vajanaphanich, M., Schultz, C., Tsien, R.Y., Traynor-Kaplan, A.E., Pandol, S.J. and Barrett, K.E.
J. Clin. Invest. 1995, 96: 386-393
Download: PDF file, 1.213 KB

Long-term uncoupling of chloride secretion from intracellular calcium levels by Ins(3,4,5,6)P4

Vajanaphanich, M., Schultz, C., Rudolf, M.T., Wasserman, M., Enyedi, P., Craxton, A., Shears, S.B., Tsien, R.Y. Barrett, K.E., and Traynor-Kaplan, A.
Nature 1994, 371: 711-714
Download: PDF file, 497 KB

Membrane-permeant derivatives of cyclic AMP optimized for high potency, prolonged activity, or rapid reversibility

Schultz, C., Vajanaphanich, M., Genieser, H.G., Jastorff, B., Barrett, K.E., and Tsien, R.Y.
Mol. Pharmacol. 1994, 46: 702-708
Download: PDF file, 1.092 KB

Acetoxymethyl esters of phosphates: enhancement of the permeability and potency of cAMP

Schultz, C., Vajanaphanich, M., Harootunian, A.T., Sammak, P.J., Barrett, K.E., and Tsien, R.Y.
J. Biol. Chem. 1993, 268: 6316-6322
Download: PDF file, 1.316 KB

Publications