Custom Synthesis
SiChem synthesizes building blocks and final products
for
- Medicinal research
- Pharmaceutical Research
- Lead compound development
- Preparative and analytical chemistry.
A special field of expertise is the preparation of biologically and pharmacologically active compounds with increased bioavailibity (prodrugs).
Some of SiChem's successful custom syntheses in
the last years:
- Lead development of a candidate against cystic fibrosis
- Synthesis of a drug candidate functionalized for radiolabeling
- Synthesis of a focussed HDAC inhibitor library
- Lead development of allosteric kinase inhibitors
- Polymorphismanalysis for generic drug synthesis
- Purification and packing of ultrapure compounds for analytics of proteins
- Preparation of a surface-coating compound for microarray applications
Our very well equipped synthesis lab is complemented by state-of-the-art analytical equipment:
Analytical equipment
- HPLC-MS, HPLC-UV, HPLC-RI
- NMR (200 and 400 MHz, 1H, 13C, 31P, 19F)
- x-ray
- Melting point determination
Preparative equipment
- Discontinuous chromatography
- Continious chromatography (Licosep - Novasep)